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9 Cards in this Set
- Front
- Back
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Major organ involved with drug elimination?
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Kidney
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Parameters for glomerular filtration?
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molecular size
blood level of drug plasma protein binding degree of dissociation at urinary pH |
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Ideal characterisitcs necessary for excretion:
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not excessively large
high concetration gradient between plasma & filtration only free drugs are filtered highly polar |
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Acidic urine promotes what
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recycling of weak acids leading to an increase in duration of action
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Alkaline urine promotes what?
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Acceleration excretion of weak acids
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Name 4 important characteristics of tubular secretion:
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energy-dependant
can be blocked by metabolic inhibitors can be saturated exists for both anions & cations |
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Probenecid illustrates what?
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blocks tubular secretion of penecillin, increasing duration of action of penicillin
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With regards to drug elimination, the idea of a concerted effort refers to what?
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The liver and kidneys must act together. Biotransformatin needed by liver, then presentation to kidneys for excretion.
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Define enterohepatic circulation:
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Drug is excreted by the liver into bile, then into intestine. If it is THEN reabsorbed by the GI tract, this is called enterohepatic circulation
e.g. steroid hormones |
