Specific Pathology 08: Vasculitides

Front 1

resistance vessels (2)

Back 1

small arteries
arterioles

Front 2

small arteries are ___ in diameter

Back 2

<2 mm

Front 3

in arterioles, ___ aren't identifiable

Back 3

3 layers

Front 4

vasculitis is ___. it can cause ___ to tissues

Back 4

inflammation of vessels causing luminal narrowing
ischemia

Front 5

___ happens to an ischemic luminal organ

Back 5

ulceration

Front 6

3 causes of vasculitis

Back 6

immune complexes
cell mediated immunity
anti-endothelial Abs

Front 7

2 kinds of large artery vasculitis

Back 7

giant cell (temporal) arteritis
takayasu arteritis

Front 8

giant cell arteritis is a ___ inflammation of ___. it only affects people over ___. it affects women ___ times more frequently than men.

Back 8

granulomatous
external branches of carotid a.
50
2.5

Front 9

T/F: giant cell arteritis is rare

Back 9

false

Front 10

giant cell arteritis most commonly affects ___ (3) arteries.

Back 10

temporal
vertebral
ophthalmic

Front 11

rarely, GCA can occur at ___ (3)

Back 11

coronaries
aorta
GI arteries

Front 12

if the ophthalmic artery is affected, ___ can result

Back 12

sudden blindness

Front 13

diagnosis of GCA is via ___

Back 13

biopsy

Front 14

treatment of GCA is with ___

Back 14

steroids

Front 15

any chronic inflammatory disease can cause ___

Back 15

anemia

Front 16

GCA presents with (6)

Back 16

headache
fever
weakness
weight loss
elevated ESR
polymyalgia rheumatica

Front 17

takayasu's arteritis is aka (2)

Back 17

granulomatous-sclerosing aortitis
pulseless disease

Front 18

TA is ___. it mostly affects ___ in ___.

Back 18

stenosing inflammation of aortic arch and tributaries
young women
far east

Front 19

TA presents with (3)

Back 19

ocular disturbances
weakened pulse in upper extremities
neurologic disorders

Front 20

2 kinds of medium artery vasculitis

Back 20

polyarteritis nodosa
kawasaki's disease

Front 21

PAN is ___ attacking arteries to ___ (7).

Back 21

systemic vasculitis
kidneys
heart
liver
GIT
testes
skeletal muscle
PNS

Front 22

PAN does not affect ___

Back 22

pulmonary arteries

Front 23

acute PAN lesions have (3)

Back 23

fibrinoid necrosis
inflammatory cells (neutrophils) in wall
luminal thrombus

Front 24

healing PAN lesions have

Back 24

intiimal fibroblast proliferation
chronic inflammatory cells (macrophages)

Front 25

healed PAN lesions have (3)

Back 25

intimal fibrosis
medial fibrosis
loss of elastica interna

Front 26

T/F: all 3 lesions may be present in different segments of same artery

Back 26

true

Front 27

PAN mostly affects ___. It presents with ___ (7)

Back 27

young and middle aged people
fever
fatigue
weakness
renal symptoms
musculoskeletal symptoms
GIT symptoms
PNS symptoms

Front 28

PAN lab findings

Back 28

normocytic anemia
elevated ESR
30%: HBsAg

Front 29

PAN treatment (2)

Back 29

steroids
cyclophosphamide

Front 30

PAN inflammation is more common at ___, where it can cause ___

Back 30

bifurcations
microaneurysm

Front 31

PAN inflammation can trigger release of ___, which can cause.

Back 31

procoagulatory proteins
thrombosis

Front 32

3 kinds of small vessel vasculitis

Back 32

ANCA associated
immune complex associated
others

Front 33

treatment for small vessel vasculitis (2)

Back 33

steroids
cyclophosphamide

Front 34

3 kinds of ANCA-associated vasculitis

Back 34

microscopic polyangiitis
wegener's granulomatosis
churg-strauss angiitis and granulomatosis

Front 35

microscopic polyangiitis can be identified serologically by ___

Back 35

P-ANCA

Front 36

P-ANCA Abs are against

Back 36

MPO

Front 37

MP presents with (2)

Back 37

glomerulonephritis
pulmonary vasculitis

Front 38

glomerulonephritis manifests as (3)

Back 38

hematuria
proteinuria
renal failure

Front 39

pulmonary vascultis manifests as (2)

Back 39

pneumonitis
hemoptysis

Front 40

Wegener's granulomatosis presents with (3)

Back 40

necrotizing granulomas of respiratory tract
granulomatous vasculitis (RT and elsewhere)
glomerulonephritis

Front 41

T/F: WG is common

Back 41

false

Front 42

WG can be identified serologically by ___. these are Abs against

Back 42

C-ANCA
proteinase 3

Front 43

like MP, WG symptoms include ___ (2). they also include ___ (4)

Back 43

hemoptysis
renal failure
arthritis
neuritis
rash
myalgia

Front 44

Churg-Strauss is associated with ___

Back 44

P-ANCA

Front 45

Churg-Strauss is aka ___. it is characterized by ___

Back 45

allergic angiitis
eosinophilis and granulomas of venules and capillaries

Front 46

Churg-Strauss affects

Back 46

pulmonary vessels
nerves
heart

Front 47

3 kinds of immune complex associated vasculitis

Back 47

Henoch-Schönlein purpura
cryoglobulinemic purpura
cutaneous leukocytoclastic vasculitis

Front 48

Henoch-Schönlein presents with (4)

Back 48

purpura
arthralgia
colicky abdominal pain
50%: renal symtpoms

Front 49

T/F: Henoch-Schönlein has a good prognosis

Back 49

true

Front 50

Henoch-Schönlein usually follows ___. It is most common in ___ age ___

Back 50

URTI
children
3-8

Front 51

cryoglobulinemic purpura presents with (3)

Back 51

purpura
arthralgia
glomerulonephritis

Front 52

cryoglobulinemic purpura is usually associated with ___

Back 52

HCV

Front 53

CP serum has ___ and low ___ (2)

Back 53

cryoglobulins
C3
C4

Front 54

in cutaneous leukocytoclastic vasculitis, ___ infiltrates ___ (2). ___ may also be present.

Back 54

neutrophils
venules
capillaries
fibrinoid necrosis

Front 55

CLV presents with and has 3 kinds of etiologies:

Back 55

palpable purpura
idiopathic
iatrogenic
infective

Front 56

treatment for CLV is ___

Back 56

symptomatic

Front 57

non-ANCA, non-immune related causes of small vessel vasculitis (2)

Back 57

paraneoplastic
IBD