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29 Cards in this Set
- Front
- Back
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Tox: Acetaminophen
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N-acetylcysteine
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Tox: Salicylates
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NaHCO3- alkalinize urine, dialysis- ionized drugs cannot easily cross the plasma membrane
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Tox: Amphetamines- NH3
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NH4Cl- acidify urine
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Tox: Anticholinesterase, Organophoshate
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Atropine- muscarinic antagonist
Pralidoxime- to reactivate AChE |
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Tox: Antimuscarinic, anticholinergic agents
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Physo*stig*mine- stimulates nicotinic and muscarinic
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Tox: Beta blockers
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Glucagon
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Tox: Digitalis- blocks basolateral NaK ATPase, increase Na in cell, increased Ca in cell- Na out/Ca in--> arrhthmias
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Correct hyperglycemia- hypokalemia (potentiates digitalis), acidosis
Lidocaine- antiarrythmic, blocks Ca2+ inflow Anti-dig Fab fragments Mg2+ - Ca channel antagonist |
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Tox: Iron
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Deferoxamine- chelator
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Tox: Lead
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CaEDTA
Dimercaprol Succimer Penicillamine |
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Tox: Arsenic, mercury, gold
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Dimercaprol
Succimer |
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Tox: Arsenic, Copper, Gold
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Penicillamine
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Tox: Cyanide-- blocks cytochrome P450
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Nitrite, Hydroxocobalamin
- both release CN from cytochrome system Thiosulfate--> Thiocyanate (harmless) |
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Methemoglobin
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Methylene blue
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Carbon monoxide
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100% O2, hyperbaric
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Methanol, ethylene glycol
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Ethanol
Fomepizole- inhibits alcohol dehydrogenase Dialysis |
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Tox: Cyanide-- blocks cytochrome P450
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Nitrite
Hydroxocobalamin- release CN from cytochrome system Thiosulfate--> Thiocyanate (harmless) |
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Tox: Methemoglobin
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Methylene blue
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Tox: Carbon monoxide
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100% O2, hyperbaric
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Tox: Methanol, ethylene glycol
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Ethanol
Fomepizole- inhibits alcohol dehydrogenase Dialysis |
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Tox: Opioids
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Naloxone/Naltrexone
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Tox: Benzodiazepines
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Flumazenil
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Tox: TCAs--> respiratory acidosis
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NaHCO3- alkalinizes serum
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Tox: Heparin
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Protamine
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Tox: Warfarin
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Vitamin K, Fresh Frozen Plasma
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Tox: - tPA, streptokinase
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Aminocaproic acid- like lysine, inhibits enzymes that attach to lysine, like plasmin
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What does lead poisoning look like?
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Lead Lines on gingivae and epiphyses
Encephalopathy, Erythrocyte basophilic stippling Abdominal colic, Sideroblastic anemia Drops- wrist and foot Succimer to treat for kids |
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What does iron poisoning look like?
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Causes peroxidation of membrane lipids
Acute- gastric bleeding Chronic- metabolic acidosis, GI scarring |
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What organophosphate poisoning is/does
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activates Ach N, M
D- diarrhea U- urination M- miosis B- bronchospasm E- emesis L- lacrimation S- salivation Atropine- muscarinic Pralidoxime- both |
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Beta blocker overdose
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Glucagon- cAMP- Ca2+ in heart
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