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97 Cards in this Set
- Front
- Back
Where is AST (SGOT) is produced? When does it increase?
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Aspartate aminotrasferase is produced by the liver, muslce, & heart. It increases with hepatocyte damage & bile duct obstruction.
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Where is ALT (SGPT) produced? When does it increase?
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Alanine aminotransferase is produced by the liver ONLY. It increases with hepatocyte damage and bile duct obstruction.
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When does Serum Protein decrease/increase?
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-It increases with Globulin (inflammatory & neoplastic disease).
-It decreases with Albumin (hepatocyt damage). |
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What is prothrombin time (PTT) and how can you decrease it?
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PTT is clotting time.
It decreases with hepatocyte damage. |
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Fetal antigen is present in 50% f patients with ________.
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HEPATOMAS
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Cholesterol decreases with ___ ____ disease and increases with ____ _____.
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DECREASES: chronic liver disease
INCREASES: bile duct obstruction |
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Where is Serum Alkaline Phosphatase (ALK PHOS; AP) produced? When is it increased?
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It is produced by biliary ducts when damaged, the liver, bone, kidney, placenta, & intestines.
It increases with biliary obstruction, biliary neoplasm, liver damage, or liver mets. |
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How many mm total Serum Bilirubin should a NL person have?
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0.1-1.2 mg/dl
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DIRECT Serum Bilirubin increases with ___ ___ and INDIRECT Serum Bilirubin increases with ___ ___.
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DIRECT: biliary obstruction
INDIRECT: hemolytic anemia |
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What is urbilinogen?
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Urbilinogen is a bacterial by-roduct from bilirubin in the intestine
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When is urine production increased/decreased?
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INCREASED: hemolytic jaundice (too many RBCs are broken down)
DECREASED: biliary obstruction |
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When does LDH increase?
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Lactic dehydrogenase increases with obstructive jaundice
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What is the difference btwn medical jaundice d/t a HEMOLYTIC DISORDER vs. a HEPATOCYTE DISORDER?
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HEMOLYTIC: increase in amount of breakdown of RBCs done by hepatocytes and creates an increase in by-products
HEPATOCYTE: bilirubin is processed by liver, but is regurgitated back into blood stream |
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What lab values increase d/t medical(hepatic) jaundice?
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Both direct & indirect bilirubin.
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What lab values increase d/t obstructive (surgical) jaundice?
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Direct bilirubin increases & AP (as a result of epithilial damage of obstruction of bile duct)
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Is it possible to have both medical (hepatic) AND obstructive (surgical) jaundice at the same time???
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YES
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Obstructive jaundice can occur at what 3 main areas?
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Intrahepatic, @ porta hepatis, @ common bile duct (prox & dist)
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Indirect bilirubin is taken from blood and is conjugated with _____ acid in order to be secreted into bile (water soluble/direct).
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glucurenic
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Urobilinogen is created after bile enters the ____, where it is combined with bacteria. Some is excreted as ___.
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intestines, feces
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Normal Bile Duct measurements in mm:
1) At Porta Hepatis 2) At Panreatic Head 3) After cholecystectomy |
1) 2-4 mm
2) 7 mm 3) 10 mm *remember to add 1 mm to each measurement for each decade over 50 yrs old! |
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What 3 vessels create "mickey mouse"?
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CBD - left ear
PHA - right ear MPV - head |
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What is another name for the proximal CBD?
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Common Hepatic Duct
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How long is a NL GB?
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10-13 cm long
(4 cm A-P) |
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What is the capacity of a NL GB?
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30-50 ml
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The GB is ____ to the caudate lobe.
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anterior
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The GB fossae is found _____ to the GB.
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inferior
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A Phyrigian cap is a fold in the GB _____, while a Hartmann's pouch is a fold in the GB _____.
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Phyrigian cap- FUNDUS
Hartmann's pouch- NECK |
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What valves are found in the neck/cystic duct?
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Spiral valves (aka Valves of Heister)
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The NL GB wall measures ____ mm.
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3 mm or less
(4 mm with ascities) |
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The portal vein is found _____ to the CBD.
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posterior
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Porcelain GB can cause non-visulization of the GB. T/F?
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True!
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What type of biliary tree pathology is ATRESIA?
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obliteration of the extrahepatic ducts (can extend into the prox intraheptatic duct system)
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What type of biliary tree pathology is INTERPOSITION OF GB?
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absense of the CHD & cystic duct (CBD is NL)
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What type of biliary tree pathology resembles a "string of pearls" on a sonogram d/t to non-obstructive dilitations of ducts?
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Caroli's disease (can have a stone, but usually hereditary)
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What causes a choledocal cyst?
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A choledocal cysts is caused by congenital weakness of the duct wall OR an obstruction
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A patient comes in with pain, jaundice, and a palpable mass. What could his pathology be?
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Choledochal cyst
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What are the 4 types of choledocal cysts? Which 1 is most common?
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1) CYSTIC DILATATION (most common)-dilatation begins/ends sharply
2) CHODEOCHOCELE-in intraduodenal part of CBD 3) DIVERTICULUM-outpouching 4) MULTIPLE CYSTS |
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What is the surgical treatment for choledochal cysts?
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Choledochojejunostomy (connecting of the bile duct to the jejunum)
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What is the most common biliary tree pathology?
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Choledocholithiasis (stones in the bile duct)
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A patient comes in with RUQ pain/tenderness, nausea, vomiting, fever, jaundice, and weight loss. What could his pathology be?
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Choledocholithiasis (stones int he bile duct)
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Labs for choledocholithiasis reveal an increase in what 2 areas?
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AP, serum bilirubin, (& WBCs)
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Bile ducts respond to respiration or a Valsalva's Maneuver. T/F?
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False!
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A shot-gun or double-barrel sign is indicative of what?
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Choledocholithiasis (CBD & MPV parallel each other and do NOT move b.c they are lodged in CBD)
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What is cholangitis?
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Cholangitis is acute inflammation of bile ducts d/t bacteria(associated with the inflammation of the GB, liver, panc, intestine, and choledocholithiasis)
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Cholangitis is inflammation of the bile duct d/t to bacteria originating from...?
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PV, liver, lymphatics, regrug of intestinal contents, trauma/surgery, edma
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A patient comes in with RUQ pain, jaundice, & fever w/ chills. What could his pathology be?
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Cholangitis
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Sonographically, cholangitis is associated with...
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-bile duct narrowing
-marked ductile dialation -choledocholithiasis -intrahepatic bile stasis -local hepatic damage |
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What surgical treatment is available for cholangitis?
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Decompression with a permanent drain replacement
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SCLEROSING cholangitis is associated with _____ disease.
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Crohn's disease
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What are papillomas, polyps, and adenomas?
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benign tumors
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What is the most common type of benign tumor?
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adenomas
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A patient comes in with pain, jaundice, weight loss, & dyspepsia. What pathology could he have?
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A benign tumor
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Sonographically, abenign tumor appears...
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hypoechoic, non-shadowing, non-gravity dependent
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The most common type of carcinoma is _____, which arises from the _____.
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Adenocarcinomas arise in large ducts (and metastasize to lymph nodes & liver)
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A patient comes in with jaundice (painless), weight loss, vomiting, anorexia, & RUQ pain. What could his pathology be?
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carcinoma
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Sonographically, carcinoma may appear as a...
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soft-tissue lesion w/in the ductile lumen
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70-90% cases of carcinoma include gallstones. T/F?
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True
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The _____ tumor is found at the confluence of the left & right hepatic ducts.
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Klatskin
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What biliary tree pathology is PNEUMOBILIA?
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Pneumobilia is air in the biliary tree (d/t surgery or reflux)
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What biliary tree pathology is BILOMA?
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Biloma is a collection of bile (d/t surgery or rupture)
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GB pathology is usually characterized by what classic symptoms?
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Pain/nausea after eating (up to 3 hrs), positive Murphy's sign (pain: RUQ, chest, rt subscapular, upper gastric), fever, RUQ mass
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What is the mos common GB disease?
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Cholelithiasis (gallstones)
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What are 3 reasons for cholelithiasis?
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1) ABNL bile composition
2) bile stasis 3) infection |
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Gallstones of cholelithiasis are composed of what 3 things?
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1) cholesterol
2) bile pigment 3) calcium |
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Cholelithiasis is more common in African Americans. T/F?
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Flase, it is more common in American Indians
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Cholelithiasis increases with age, diabetes, and pregnancy? T/F?
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True
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What lab values increase with cholelithiasis?
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AP (somewhat AST & ALT)
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A patient comes in with RUQ pain, chest pain, & nausea/vomiting after meals. What could his pathology be?
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cholelithiasis
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Sonographically, we can diagnosis cholelithiasis based on if it exhibits WES sign. What does this stand for?
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W-wall
E-echo S-shadow |
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What is a CHOLECYSTOGRAM?
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A cholecystogram causes stones to float
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Sludge is associated with pain. T/F?
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False!
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Sludge is mainly composed of ____ ____.
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Calcium bilirubinate
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Predisposing factors for sludge include...
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-pregnancy
-cholecystitis -IV therapy -alcoholics -duct obstruction |
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Sonographically, sludge exhibits...
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non-shadowing, gravity dependency, layering effects, mimics neoplasms (or blood or pus)
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What is CHOLECYSTITIS?
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Cholecystitis is inflammation of the GB. (95% of patients have gallstones)
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What lab values will increase with cholecystitis?
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AP, Serum bilirubin, AST/ALT (& WBCs)
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A patient comes in with fever, leukocytosis, RUQ pain, nausea/vomiting, postitive Murphy's sign, & jaundice. What pathology could he have?
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Cholesystitis
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Of the 2 types of acute cholecystitis, is acalculous or calculou more common in males?
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Acalculous (and it's more fatal!)
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Acute ACLACULOUS cholecystitis is d/t changes in ___ or ___, while acute CLACULOUS cholecystitis is d/t an ____
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ACALCULOUS: vascularity or stagnant bile
CALCULOUS: obstruction |
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The HALO SIGN is classic echo feature of _____.
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Cholecystitis
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Cholecystitis can lead to what type of complications?
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-empyema of GB (pus)
-gangernous GB (no pain) -perforated GB (peritonitis) |
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Chronic cholecystitis is associatied with an enlarged GB. T/F?
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False, chronic causes GB to become small in size
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Chronic cholecystitis may develop into Porcelain GB. T/F?
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True
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_____ syndrome is a biliary-enteric fistula that forms btwn the GB and duodenum.
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Bouveret's syndrome
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____ syndrome is a stone impacted in the neck/cystic duct and erodes into adjacent CBD.
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Mirizzi's syndrome
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What is Porcelain GB?
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Porcelain GB is calicified GB walls.
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What causes porcelain GB?
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Chonic cholecystitis, toxic bile, chronic irritation of GB wall (stones), infection
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What is Hydropic GB?
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Hydropic GB is an enlarged GB containing pus, mucus, or pus d/t an obstruction of the cystic duct.
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What is Courvoisier GB?
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Courvoisier GB is enlarged d/t CBD obstruction & panc cancer.
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How does HIV GB appear sonographically?
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HIV GB has thickened walls, striations, dilation, pericholic fluid, & sludge (w/o stones)
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Polyps are benign neoplasms that shadow. T/F?
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False, they are benign neoplasms but they do NOT shadow b/c they are made of cholesterol
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What are included in HYPERPLASTIC CHOLECYSTOSES?
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-Adenomyomatosis
-Cholesterosis -Neuromatosis -Fibromatosis -Lipomatosis (these are benign non-inflammatory conditions that cause proliferation to GB wall) |
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The hyperplastic cholecystosis ADENOMYOMATOSIS is excesssive proliferation of ____ tissue characterized by formation of mucosal outpouchings called ____.
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epithelial, diverticula (aka Rokitansky-Aschoff sinuses)
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What is "Strawberry GB" also known as?
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Cholesterosis
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What is Cholesterosis?
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Cholesterosis is cholesterol deposits in the GB wall. (May be diffuse or localized)
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______ is the most common type of malignant lesion.
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Adenocarcinoma
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Sonographically, Adenocarcinoma can be recognized by...
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stones, irreg wall thickness, polypoid masses > 1 cm, intrinsic vaculature (shown with color Doppler), non-shadowing
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