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5 Cards in this Set
- Front
- Back
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Calcium source for calcium dependant constriction? (2)
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1) Intracellular release via IP3
2)Entry across cell membrane (VDCC) due to depolarization or stretch |
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Intracellular Calcium release mechanism?
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1)Ligand binds to GPCR
2)G alpha-q dissociates and activates PLC 3)PLC PIP2=>IP3 + DAG 4)IP3 activates IP3R on S.R. causing Ca2+ to be released |
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Calcium dependant constriction mechanism?
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1)Cystolic [Ca] increases
2)Calcium binds to calmodulin 3)Ca-calmodulin activates myosin light chain kinase (MLCK) 4) MLCK phosphorylates myosin cross bridges (ATP) 5)Cross bridges bind to actin 6)cross-bridge cycle => contraction MLCK activates the myosin ATPase responsible for cross bridge linking |
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Constriction in smooth muscle cells is dependent on ______?
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phosphorylation of MLC
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What does MLC Phosphatase do?
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Dephosphorylates MLC, reduces constrictions
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