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13 Cards in this Set
- Front
- Back
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Odds ratios of NRT pooled
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1.77
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OR of bupropion
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2.06
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OR of varenicline
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12 week 3.85
52 week 3.09 |
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OR nortriptyline
TCA |
2.14
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OR clonidine
alpha adrenergic agonist |
1.89
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NRT mechanism of action
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replace nicotine and reduce withdrawal
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NRT caution
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pregnancy, ? recent MI
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Bupropion mechanism of action
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inhibitor of dopamine and NE reuptake
weak antagonist at nicotine receptor |
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Bupropion dosage
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150mg daily x 3 days then BD
1 week before quit date total 7-12 weeks |
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bupropion caution
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pregnancy, seizure, MAOI, eating disorder
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varenicline mechanism
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nicotinic acetycholine receptor partial agonist (alpha4 beta2)
stimulate dopamine turn over |
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varenicline dosage
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0.5mg daily x 3 days
0.5mg BD x 4 days 1mg BD 1 week before quit date total 12 weeks to 24 weeks |
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varenicline side effects
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nausea, insomnia, suicide
caution pregnancy |
