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4 Cards in this Set
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- Back
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Denosumab (Prolia)
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MECHANISM: IgG2 monoclonal antibody - binds to RANKL.
FXN: inhibits osteoclast formation, fx, and survival DOSING: 60mg injection every 6 months used to treat: OSTEOPOROSIS |
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Zoledronic Acid
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MECHANISM: a bisphosphate, inhibits osteoclast bone breakdown (antiresorptive agent)
DOSING: can be taken via injection once per year |
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Raloxifene (EVISTA)
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MECHANISM: Estrogen agonist in some tissue (bone) and estrogen antagonist in other tissue (breast)
used to REDUCE RISK OF BREAST CANCER and to treat OSTEOPOROSIS |
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Teriparatide (FORTEO)
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1st bone anabolic agent - used to treat OSTEOPOROSIS
MECHANISM: provides intermittent PTH (fragment of PTH with short half life - provides rapid spike of PTH) (intermittent PTH = anabolic; continuous PTH = catabolic) |
