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4 Cards in this Set

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  • Back
Denosumab (Prolia)
MECHANISM: IgG2 monoclonal antibody - binds to RANKL.

FXN: inhibits osteoclast formation, fx, and survival

DOSING: 60mg injection every 6 months

used to treat: OSTEOPOROSIS
Zoledronic Acid
MECHANISM: a bisphosphate, inhibits osteoclast bone breakdown (antiresorptive agent)

DOSING: can be taken via injection once per year
Raloxifene (EVISTA)
MECHANISM: Estrogen agonist in some tissue (bone) and estrogen antagonist in other tissue (breast)

used to REDUCE RISK OF BREAST CANCER and to treat OSTEOPOROSIS
Teriparatide (FORTEO)
1st bone anabolic agent - used to treat OSTEOPOROSIS

MECHANISM: provides intermittent PTH (fragment of PTH with short half life - provides rapid spike of PTH) (intermittent PTH = anabolic; continuous PTH = catabolic)