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34 Cards in this Set

  • Front
  • Back
What are the 3 classes of dewormers used in sheep & goats?
benzimidazoles (BZ): fenbendazole, albendazole
avermectins/milbemycins: ivermectin, eprinomectin, doramectin, moxidectin
imidazothiazoles/ tetrahydropyrimidines: levamisole, pyrantel, morantel
What is the treatment for goats w/ clinical dz from Haemonchus contortus infection?
use any effective dewormer
if animal is severely ill or drug resistance status of farm is unknown use Cydectin (cattle injectable form of moxidectin)
if > 10% of animals are clinically ill
-if returned to same pasture, frequent treatments may be needed to keep goats alive: 2-3 wk intervals
-consider move to safe pasture, barn, or drylot
What are considerations when using the following dewormers for prevention/tx of Haemonchus contortus?

a. ivermectin
b. albendazole
a. ivermectin: least effective
-very high prevalence of resistance
-DON’T use in southern US UNLESS 1st proven effective
b. albendazole
-high prevalence of resistance
-withhold feed & re-dose for improved efficacy
-don’t use in 1st 3 wks of pregnancy
What are considerations when using the following dewormers for prevention/tx of Haemonchus contortus?

a. levamisole
b. moxidectin
a. levamisole
-low prevalence of resistance b/c not used much
-weigh goats before administering d/t possible toxicity
-good choice for 1st line tx if resistance status unknown
-don’t use in debilitated animals or in last 3 wks of pregnancy

b. moxidectin
-resistance becoming common where used frequently
-if minimally used on farm, no resistance unless resistant worms were purchased
-kills ivermectin resistant H. contortus: potency issue
-tx of choice for severely clinically ill animals (bottle jaw) if no resistance
-administer current products orally ONLY
-cattle injectable (Cydectin) will be formulation of choice once available
-minimize use to preserve efficacy
How can anthelmintic resistance in small ruminants be diagnosed?
DrenchRite larval development assay: U. of Georgia
-only 1 test needed per farm: pooled fecal sample from 10-12 animals
-all 3 major drug classes tested

fecal egg count (FEC) reduction test (McMaster): labor intensive
-animals divided into groups (10-15/group, balanced by sex & age) & treated as follows:
-group 1: drug to be tested
-group 2: no drug (negative control)
-FEC determined 10-14 d. after tx
-compare post tx mean FEC of control group to drug treated group
What are some methods of controlling anthelmintic resistance in small ruminants?
smart drenching program
-know resistance status of herd or flock
-sound pasture management: dec. stocking rates, use dilution strategies
-keep resistant worms off farm: quarantine & aggressively deworm all new animals
-administer proper dose: goats: 1.5-2x > cattle & sheep, give orally
-utilize host physiology: restrict feed intake for 24 hrs prior to tx &/or repeat tx in 12 hrs

perform only selective tx using FAMACHA &/or FEC
-tx goats w/ highest 1/3 of FEC
-following tx, >95% of eggs being shed by untreated goats: REFUGIA
-more of pop'n in refugia, slower resistance develops
What are the most common species of nematodes that affect small ruminants?
Haemonchus contortus
Ostertagia spp.
Trichostrongylus spp.
What clinical signs are assoc. w/ nematode infection in small ruminants, & specifically w/ Hameonchus contortus infection?
chronic poor doing, diarrhea, failure to thrive, death

H. contortus: anemia, hypoproteinemia (--> bottle jaw), chronic diarrhea, sudden death
coccidiosis

a. occurrence
b. clinical signs
c. dx
a. most commonly a problem in young animals
-onset of clinical dz occurs w/ stress: change in diet, change in weather, parturition
-generally a man made dz caused by overcrowding & unsanitary conditions
b. diarrhea: mucus, watery, usually NOT bloody but may be
-may be acute or chronic w/ wasting/stunting
-fever, off feed, dehydration, weakness, rough hair coat
-death in severe cases
c. based on signs (diarrhea) AND presence of many oocysts on direct fecal exam or float
-signs may precede appearance of oocysts in feces
-interpretation of presence of oocysts in some animals difficult
coccidiosis

a. tx
b. prevention
a. sulfas, amprolium
-tx whole group to prevent spread
-little value for affected individuals after showing signs
-inhibit coccidial development: prophylaxis
b. sulfas, amprolium, or other coccidiostats in feed or water
-limit intake of sporulated oocysts by young: enough to produce immunity but not dz
-prevent buildup of oocysts: avoid overcrowding
keratoconjunctivitis

a. etiology
b. signs
c. tx
a. Chlamydia, Mycoplasma, Rickettsia
b. lacrimation, corneal cloudiness --> central opacity
c. topical (tetracycline), parenteral (oxytet) Abs
contangious ecthyma

a. etiology
b. lesions
c. tx
a. poxvirus
b. proliferative lesions (papules, vesicles, pustules) on lips, gums, teats, etc.
c. none: usually self-limiting

zoonotic
What are some cutaneous parasites of small ruminants?
lice, Demodex, acariasis, ear mites
scrapie

a. clinical signs
b. identification program
a. progressive fatal encephalitis of mature sheep (1-5 yo)
pruritis, inappropriate nervousness, or excitement, fine tremors, ataxia, progresses to wt. loss, blindness, abortion, extreme pruritis
b. determine if animals need to be tagged
obtain premise/flock number
select approved ID system best for you
set up record system: need to keep ID records for 5 yrs
make sure any animal leaving operation has a tag
make sure every breeding animal & sexually intact goat crossing state lines has a certificate of veterinary inspection (CVI)

reportable dz
bluetongue

a. transmission
b. signalment
c. signs
d. dx
e. tx
a. virus transmitted by midges of genus Culicoides
b. sheep
c. vasculitis of several organ systems (fever, lameness, diarrhea, pneumonia, swelling of lips, muzzle & ears)
d. serology
e. supportive care
copper toxicosis

a. signalment
b. signs
c. dx
d. tx
a. sheep very sensitive to copper in diet, esp. young growing lambs
b. acute hemolytic crisis: usually fatal
c. measure Cu levels in feed, blood, liver, kidney
d. add ammonium molybdenate & sodium sulfate to feed or drench orally
listeriosis

a. etiology
b. source of infection
c. signs
d. tx
a. Listeria monocytogenes
b. spoiled silage or rotting hay
c. acute meningoencephalitis, unilateral signs
d. high doses of penicillin, tetracycline (must tx early for response)
caprine arthritis encephalitis virus

a. etiology
b. 2 major forms
c. transmission
d. dx
e. prevention
a. lentivirus (retrovirus family)
b. polysynovitis/arthritis: most common
-most common in adults: carpi most commonly affected

leukoencephalomyelitis
-affects kids 2-6 mo.: rear leg paresis --> paralysis of all limbs
c. via colostrum/milk
d. signs, necropsy, AGID, ELISA
e. raise CAEV kids: pasteurize colostrum, use negative milk
-kids may be tested at 6 mo. (after decline of maternal Ab)
contagious foot rot

a. etiology
b. signs
c. tx
d. prevention
a. Dichelobacter (Bacteroides) nodusus, 2º Fusobacterium necrophorum
b. lameness, redness & swelling in interdigital area, undermining of sole & wall, characteristic foul odor
c. foot trimming, footbaths, ABs (penicillin, tetracycline), segregate affected animals, 10% zinc sulfate
d. footbaths, vaccine (only used in special cases), cull animals still infected after repeated tx
polioencephalomalacia

a. pathogenesis
b. signs
c. tx
a. CNS disorder d/t thiamine deficiency --> necrosis of cortical gray matter
-most common cause: ruminal thiamine consumption by bacterial thiaminases
-usually affects grain fed animals
b. anorexia, staggering, opisthotonus, star gazing, blindness, convulsions, head pressing, etc.
c. thiamine IV repeatedly, supportive care
Q fever

a. etiology
b. signs
c. tx
a. Coxiella burnetti
b. most infections are asymptomatic; may cause late abortion or delivery of weak offspring
c. tetracycline

zoonotic
toxoplasmosis

a. signs
b. transmission
a. major cause of abortion in sheep & goats
-no clinical illness in adults
b. ingestion of oocysts from cat feces

zoonotic
What are some miscellaneous causes of abortion in small ruminants?
enzootic abortion, Campylobacter spp.
What is the tx for small ruminant attacked by a dog?
clean wounds, ABs, make sure Clostridial vaccine is current
joint ill

a. pathogenesis
b. dx
c. tx
a. complication/sequelae to infection by a variety of microorgs
-often a sequela to FPT
b. clinical signs, rads, U/S, CBC, arthrocentesis/culture
c. ABs, joint lavage, arthrotomy, etc.
chalmydial polyarthritis

a. etiology
b. signalment
c. clinical signs
d. tx
a. Chlamydia psittaci
b. sheep (primarily 1-8 mo.) primarily, also goats, & calves
c. stiffness, shifting leg lameness, fever, etc.
-may also cause keratoconjunctivitis: different strain causes enzootic abortion in ewes (EAE)
d. tetracycline, macrolides
mycosplasmal arthritis

a. signalment
b. transmission
c. dx
d. tx
a. goats > sheep, more common in young animals
b. milk/colostrum
c. culture on mycosplasmal media
d. tetracyclines, macrolides (generally do not cure)
-cull, segregate, isolate
Erysipelothrix arthritis

a. etiology
b. signalment
c. transmission
d. signs
e. tx
a. Erysipelothrix rhusiopathiae (insidiosa)
b. lambs
c. after use of contaminated dip tank, docking, castration, etc. (organism in soil & manure)
d. acute (or chronic) nonsuppurative arthritis, poor wt. gain
e. penicillin (will respond if early in course)
Johne's dz

a. etiology
b. signalment
c. signs
d. dx
e. control
a. Mycobacterium avium paratuberculosis
b. signs most common at 2-5 yo
c. wt. loss & emaciation w/o diarrhea (note difference from cattle)
d. histopath (acid fast stains) of terminal ileum/ileocecal ln

serology
-ELISA: use only for herd level screening
-seropositives must be confirmed w/ more specific test: cross reacts w/ CL

-special cultures: sheep strains grow poorly
-DNA probes
e. remove affected animals from herd
abomasal emptying defect

a. signalment
b. clinical signs
c. dx
a. black faced sheep (ex. Suffolk)
b. wt. loss, inappetance, abdominal distension
c. ↑ rumen Cl, necropsy
quick pneumonia

a. etiology
b. signs
c. dx
d. tx
a. Manheimia haemolytica (A1: cattle, A2: sheep), Pasteurella spp.
b. septicemia, sudden death, fever in lambs
c. necropsy (fibrinous pneumonia), C/S
d. ABs: tx early based on fever
What is the tx for the following respiratory pathogens:

a. Chlamydia
b. Mycoplasma
a. tylosin or tetracycline
b. tetracycline or macrolides
viral pneumonia

a. etiology
b. vaccination
a. PI3 (pathogenicity uncertain), RSV, adenovirus
b. intranasal IBR-PI3 used in lambs: ½ cattle dose per nostril (IFN production)
OPPV

a. etiology
b. closely related to...
c. signalment
d. signs
a. retrovirus
b. CAEV (caprine arthritis encephalitis virus)
c. 3-4 yo sheep
d. coughing & dyspnea w/ exercise
-also encephalitis, arthritis, mastitis at necropsy