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18 Cards in this Set
- Front
- Back
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Best way to diagnose bullous disease?
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biopsy
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Bullous diseases can be:
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autoimmune against something that holds the skin together
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Associated with subclinical gluten-sensitive enteropathy; IgA deposition:
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Dermatitis Herpetiformis
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Can be associated with small bowel lymphoma:
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Dermatitis Herpetiformis
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Where is the separation in DH?
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subepidermal
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What are the antibodies found in DH?
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Anti-endomesial antibodies
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What WBC's are seen in DH?
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neutrophils
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Intradermal, blistering, antibodies against cell-cell adhesions, neoplasm?
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pemphigus
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Lesions appear first in the mouth in 60% of cases or at a site of trauma or burn:
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pemphigus vulgaris
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Mucosal erosions, thin-walled and flaccid bullae that appear on normal skin and mucous membranes:
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pemphigus vulgaris
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What signs are positive in pemphigus vulgaris?
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nikolsky's and Asboe-Hansen signs
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What is asboe-hansen sign?
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Elicited by direct pressure on an intact bullae
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Pemphigus vulgaris can lead to what difficulty?
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swallowing
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What antibodies are seen in pemphigus vulgaris?
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anti-desmoglein 1 and anti-desmoglein 3 autoantibodies
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What populations get pemphigus vulgaris?
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mediterranean and jewish
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What antibodies are seen in bullous pemphigoid?
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Antibodies bind to antigens BP230 and BP180
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Will bullous pemphigoid scar?
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yes; it is below the DE line
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Pemphigus or pemphigoid: which occurs in the more elderly population?
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pemphigoid
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