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19 Cards in this Set
- Front
- Back
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use of shave biopsies in melanoma
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never use shave biopsy for diagnosis
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Margin attainment goal for surgery of in situ melanoma
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wide excision of 0.5 cm
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Margin attainment goal for surgery of tumors <1mm thick
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1cm margin
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Margin attainment goal for surgery of tumors 1-2mm thick
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1-2cm margin
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Margin attainment goal for surgery of tumors 2-4mm thick
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2cm margin
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Margin attainment goal for surgery of tumors >4mm thick
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at least 2cm margin
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sentinel node mapping and eval for lesions how thick?
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>1 mm thick
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agent used in adjuvant melanoma treatment
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interferon a high dose. Approved for lesions thicker than 4mm or involving lymph nodes
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toxicities with HD interferon a
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fever, chill, fatigue, headache, nausea, wt loss, myelosuppression, depression, hypothyroidism
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HD interferon dose modification due to ANC
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ANC < 250= hold x 1 week, then resume with 33-50% dose when ANC>250
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HD interferon dose mod due to AST
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if AST > 10x normal, hold until AST are <3x normal and modify dose to 33-50%
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HD interferon dose mod due to wt loss
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if >10% wt loss, hold 1 wk and resume 33-50% dose with nutrition consult
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cutoff in melanoma for treatment with adjuvant therapy
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localized melanoma > 4mm thick or node positive patients
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dose of IL-2 for melanoma
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600,000 IU/kg/dose q8h x 14 doses
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toxicities of IL-2
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capillary leak syndrome (hypotension, visceral edema, dyspnea, tachycardia), pruritis, eosinophilia, marrow suppression, increase LFTs, N/V
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only FDA approved chemo for metastatic melanoma
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dacarbazine
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combination chemo for met melanoma
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CVD= increased response, no increased OS vs singe agent
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basal cell carcinoma (BCC) vs squamous cell cancer (SCC) in aggressiveness
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SCC have more rapid growth and potential to metastasize
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treatment for BCC/SCC
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chemo not typically used. Surgery, RT, Cryo, photodynamic
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