Skin: 8. Blue : Herpes Simples, Chickenpox, Smallpox

Front 1

if looking at a stain and you see intranuclear inclusion bodies, what type of virus are you looking at?

Back 1

Herpes virus

Front 2

if you are looking at a stain and you see multinucleated giant cells (synctia) what are you looking at?

***

Back 2

Herpesvirus

Front 3

• What are the 2 groups of herpes viruses?

Back 3

o Neurotropic
o Lymphotropic

Front 4

• Where do neurotropic herpes virsues reside? Where do they effect?

Back 4

o They reside in neurons but they affect skin, mucous membranes and NS

Front 5

• Lymphotropic herpes viruses affect what?

Back 5

o T cells

Front 6

• Herpes simplex viruses 1 and 2 are what type of herpes virus?

Back 6

o Neurotropic

Front 7

• varicella-zoster virus is what type of herpes virus?

Back 7

o Neurotropic

Front 8

• EBV is what type of herpes virus?

Back 8

o Lymphotropic

Front 9

• Cytomegalovirus (CMV) is what type of herpes virus?

Back 9

o Lymphotropic

Front 10

• HHV8 is what type of herpes virus

Back 10

o Lymphotropic

Front 11

• What are 2 hallmarks of herpes virus?

Back 11

o Lifelong infection
o Latency

Front 12

HSV-1, 2 and VZV have the ability to _____ and cause recurrent disease

Back 12

reactivate

Front 13

is reactivation normally symptomatic or asymptomatic? are they transmissible?

Back 13

they are often asymptomatic but still transmissible! these lil F'ers are good

Front 14

expression of CMV and EBV primarily reactivate under what condition?

Back 14

immuno-suppression

Front 15

what is responsible for maintaining the latent state of herpes viruses?

Back 15

Latency-associated RNA transcript,

continually expressed,
influence cellular functions.

Front 16

slide 5 has a nice chart of all the diseases we need to know

Back 16

maybe make cards on it?

Front 17

what is one of the most frequent causes of encephalitis?

Back 17

HSV 1

Front 18

what is one of the most frequent causes of meningitis?

Back 18

HSV 2

Front 19

which HSV causes conjunctivitis? 1, 2, or both?

Back 19

HSV 1

Front 20

which HSV causes genital herpes? 1, 2, or both?

Back 20

both

Front 21

primary clinical presentation of herpes simplex virus type 1?

Back 21

infection of the mouth (Gingivostomatitis)

babies get it from kisses and whatnot

Front 22

what is Herpes labialis

Back 22

cold sores”;lips, reactivation of latent virus (due to disease, trauma), recurrent (adolescents/adults).

Front 23

what is Gingivostomatitis

Back 23

infection of the mouth seen in HSV 1

Front 24

what is keratoconjunctivitis? what is it seen in?

Back 24

pinking of the eye, due to herpes

can be recurrent

can leave scars on the cornea

Front 25

an infant is brought to you with red spots and patches especially around places of eczema and dermatitis. you see these on the face and especially around the mouth. what do they likely have?

Back 25

eczema herpeticum

Front 26

Meningoencephalitis is seen with what?

Back 26

HSV

Front 27

a man comes in to your office with what appears to be herpes. You take a sexual history and find nothing remarkable, and there is no history of herpes in the family. You find out your patient is a wrestler, which leads you to the diagnosis of

Back 27

herpes gladiatorum

spreads from rubbing up on each other and one person having the herp.

Front 28

what is herpetic whitlow? who is affected

Back 28

herpes acquired by docs who didnt wear gloves while treating ppl with herpes

see it on the finger

can be seen in babies who suck their thumb

Front 29

a patient comes to your office with a few lesions on the hands, tongue and buttock. the lesions look like bulls-eyes or targets. what do they have?

Back 29

erythema multiforme

associated with Herpes

Front 30

in erythema multiforme is virus found in the lesion?

Back 30

no, it is strange

they detect viral protein and nucleic acid, but no whole virus

Front 31

when is HSV1 normally acquired?

Back 31

childhood

Front 32

what normally passes HSV1

Back 32

oral secretion

Front 33

a patient with HSV asks you if they are infectious when they don't have cold sores or any symptoms...are they?

Back 33

HELL YEA THEY ARE

steer clear! ahah

Front 34

what is auto-inoculation of herpes?

Back 34

it is the fact that it can spread either from mouth to genitals or vice versa

Front 35

a concerned mother brings in her 14 year old. She is upset because her daughter thinks she is having sex due to the girl now having genital herpes. Is the mom right?

Back 35

it depends. if she had oral herpes it could have spread via auto-inoculation

Front 36

can the immune system eliminate herpes simplex virus 1 ?

Back 36

no! sorrrryyy

it does control symptomotology

Front 37

what are the 2 common names for varicella-zoster virus

Back 37

chicken pox

shingles (when reactivated)

Front 38

where does varicella-zoster virus sit dormant?

Back 38

in neurons of the spinal cord

Front 39

how often do you normally experience a reactivation of varicella-zoster virus

Back 39

once if at all

Front 40

is chickenpox the primary or reactivated form of varicella-zoster virus

Back 40

primary

seen in kids

Front 41

what is zoster (shingles)?

Back 41

varicella-zoster virus

reactivation of latent virus,
adults.Thoracic or trigeminal. Post-herpetic
neuralgia.

Front 42

an adult male comes in with painful rashing that starts midline on the stomach and spreads in a line to the back...what does your patient have?

Back 42

herpes zoster (shingles)

Front 43

infections of herpes varicella-zoster virus leads to what?

Back 43

CHICKENPOX NOT SHINGLES

Front 44

a patient comes to you and says hey doc my kid has chickenpox. Grandma lives at home and I am worried about her getting shingles. is this going to happen?

Back 44

NO! contact leads to CHICKENPOX not shingles

shingles only occurs due to reactivation of own virus

Front 45

what are the 2 ways you can contract chickenpox?

Back 45

Droplet (respiratory) transmission, contact with lesions

Front 46

infant presents with a high fever for about 2 days. after being watched in the ER to make sure no serious damage has occured the fever subsides and a rash appears. what is going on with the child?

Back 46

they have HHV 6 (known as Roseola)

Front 47

HHV7 causes what?

Back 47

roseola (again the fever for 2 days followed by rash)

Front 48

what leads to Kaposi's sarcoma?

Back 48

HHV 8

Front 49

a patient presents with a spindle cell tumor on the surface of the skin. It is brownish to deep red (noting that it is highly vascularized) what does this person have, and what causes it?

Back 49

Kaposi's sarcoma

HHV8

Front 50

for serious herpes, what treatment is given?

Back 50

inhibit viral DNA polymerase

Front 51

what is the largest virus (both physically and genetically)

Back 51

Poxviruses

Front 52

what is the causative agent of small pox?

Back 52

variola virus. Only infectious agent
eradicated from world.

Front 53

vaccinia virus what used for what?

Back 53

vaccine for smallpox

Front 54

did smallpox affect other animals or was it human specific

Back 54

human specific

Front 55

prior to getting the rash of small pox, what would happen?

Back 55

patients would have 3 days of flu like symptoms where they were HIGHLY contagious

Front 56

what is Molluscum Contagiosum

Back 56

poxvirus skin infections

bump filled with cheesey material

can be contracted sexually (seen in teenagers)

Front 57

what is Orf?

Back 57

sheep virus

see lesions

poxvirus skin infection

Front 58

what are
Milker’s nodules

Back 58

paravaccinia virus

seen in farmers who milk the cows themselves

see lesions due to poxvirus

Front 59

a teenage male presents in your office with a large bump on the skin. He claims that he tried to "pop it like a zit" and a white cheesey material came out. upon questioning you find out the teen is sexually active. What is your diagnosis?

Back 59

Molluscum Contagiosum

Front 60

HSV 1

Target Cell Type

Back 60

Mucoepithelia

Front 61

HSV 2

Target Cell Type

Back 61

Mucoepithelia

Front 62

Varicella Zoster virus (VSV)


Target Cell Type

Back 62

Mucoepithelia

Front 63

Epstein-Barr Virus (EBV)


Target Cell Type

Back 63

B lymphocyte, epithelia

Front 64

Cytomegalovirus (CMV)


Target Cell Type

Back 64

Epithelia, monocytes, lymphocytes

Front 65

Human herpes virus -6 (HHV-6

Target Cell Type

Back 65

T lymphocytes and others

Front 66

Human herpes virus-7 (HHV-7)


Target Cell Type

Back 66

T lymphocytes and others

Front 67

Human herpes virus-8 (HHV-8)
Kaposi's sarcoma- associated herpes virus (KSHV)


Target Cell Type

Back 67

Endothelial cells

Front 68

HSV 1

Latency?

Back 68

Neuron

Front 69

HSV 2

Latency?

Back 69

Neuron

Front 70

Varicella Zoster Virus

Latency?

Back 70

Neuron

Front 71

EBV

latency?

Back 71

B lymphocytes

Front 72

Cytomegalovirus (CMV)

latency?

Back 72

Monocytes, lymphocytes and possibly others

Front 73

Human herpes virus -6 (HHV-6)


latency?

Back 73

T lymphocytes and others

Front 74

Human herpes virus -7 (HHV-7)


latency?

Back 74

T lymphocytes and others

Front 75

Human herpes virus-8 (HHV-8)
Kaposi's sarcoma- associated herpes virus (KSHV)

latency?

Back 75

unknown

Front 76

Human herpes virus-8 (HHV-8)
Kaposi's sarcoma- associated herpes virus (KSHV)

transmission?

Back 76

Exchange of body fluids?

Front 77

Human herpes virus -7 (HHV-7)

transmission?

Back 77

Unknown

Front 78

Human herpes virus -6 (HHV-6)

transmission?

Back 78

Contact, respiratory route

Front 79

Cytomegalovirus (CMV)


transmission?

Back 79

Contact, blood transfusions, transplantation, congenital

Front 80

Epstein-Barr Virus (EBV)

transmission

Back 80

Saliva

Front 81

Varicella Zoster virus (VSV)


transmission

Back 81

Contact or respiratory route

Front 82

Herpes simplex-2 (HSV-2)


transmission

Back 82

Close contact usually sexual

Front 83

Herpes simplex-1 (HSV-1)


transmission

Back 83

Close contact