Skin

Front 1

marker for Langerhans cells

Back 1

CD1a

Front 2

anyphylatoxins of complement

Back 2

C3a, C4a, C5a

Front 3

most powerful PMN chemoattractant

Back 3

C5a

Front 4

MAC complex

Back 4

C5b, C6, C7, C8, C9

Front 5

TH1 cytokines

Back 5

IFN-g, TNF-b, IL-2

Front 6

TH2

Back 6

humoral response, IL-4,5,6,10

Front 7

IL-4

Back 7

stimulates B cells to produce IgE

Front 8

IL-5

Back 8

promotes eosinophils

Front 9

!L-10

Back 9

inhibits TH1

Front 10

antimicrobial peptides

Back 10

defensins (hBD-2) and cathelicidens (LL37)

Front 11

what cells can present MHCII

Back 11

macrophages/monocytes, dendritic cells, B-cells

Front 12

4 regions of TCR

Back 12

variable diversty joining constant

Front 13

2nd costim molecules

Back 13

CD28 on T cells, B7 on APC

Front 14

B cells markers (3)

Back 14

CD19+,20+, 22+

Front 15

IgM

Back 15

largest, classic complement

Front 16

IgG

Back 16

most abundant, classic complement, autoimmune

Front 17

IgA

Back 17

mucosal, alternative complement

Front 18

IgE

Back 18

anaphylaxis

Front 19

ACD cause in nail polish

Back 19

tosylamide formaldehyde

Front 20

adhesive allergen

Back 20

colophony

Front 21

allergen in poison oak

Back 21

urushiol

Front 22

cross reactions with posion oak

Back 22

mango skin, non-American Tochicodendron trees, cashew nut oil, ginko biloba

Front 23

allergen in hair dye

Back 23

p-phenylenediamine (PPD)

Front 24

allergen in hair wave

Back 24

glyceryl monothioglycolate

Front 25

Hertoghe’s Sign

Back 25

loss of lateral eye brow, sign of atopic derm

Front 26

gene defect in NF1

Back 26

neurofibromin

Front 27

gene defect in NF2

Back 27

Schwannomin or Merlin

Front 28

gene defect in tuberous sclerosis

Back 28

TSC1 (hamartin) or TSC2 (tuberin)

Front 29

gene defect in Marfan's syndrome

Back 29

fibrillin

Front 30

Crowe's sign

Back 30

seen in NF1, axillary or ingunal freckling

Front 31

tuberous sclerosis triad

Back 31

adenoma sebaceum, mental deficicency and epilepsy

Front 32

Koenen's tumor

Back 32

periungal fibromas, pathogneumonic for tubersous sclerosis

Front 33

defect in Peutz Jeghers syndrome

Back 33

STK11/LKB1, tumor supressor, periorifical lentiginosis, polyps but not adenocarcinoma, incr in other CAs

Front 34

Peutz Jeghers has incr risk of which 3 cancers

Back 34

ovarian, breast, pacreas

Front 35

gene defect in Gardner's

Back 35

APC, tumor supressor; stomach cancer and epidermoid cysts, CHRPE

Front 36

congenital marker for Gardner's syndrome

Back 36

congenital hypertrophy of the repital pigment epithelium (CHRPE)

Front 37

general gene defect in XP

Back 37

defects in DNA repair

Front 38

gene defect in Cowden's, also alternative name

Back 38

multiple hamaratoma syndrome, gene defect in PTEN tumor supressor, facial trichelmoma, oral papillomas, keratotic papules

Front 39

systems that can be involved in Cowden's (6)

Back 39

skin, breast, thyroid, GI, GU, MSK

Front 40

gene defect in Alkaptonuria and the result

Back 40

defect in homogentisate 1,2 dioxygenase gene which leads to a decr amount of homogentisic acid oxidase which is required for the breakdown of phenylalanine and tyrosine

Front 41

gene defect in Fabry's disease and mode of inheritence

Back 41

defect in a-galactosidase A, x-linked recessive

Front 42

organism causing Pityriasis versicolor

Back 42

Malssezia furfur

Front 43

organism causeing tinea negra

Back 43

Exophilia wernekii

Front 44

organism causing white piedra

Back 44

Trichosporon beigelli

Front 45

organism causeing black piedra

Back 45

Piedraia hortae

Front 46

3 organims causing dermaphytoses

Back 46

Trichophyton, microsporum, epidermophyton

Front 47

trichophyton

Back 47

can infect hair, nails or skin; many microconidia and rare thin walled macroconidia

Front 48

microsporum

Back 48

can infect hair or skin, fewer microcondia and thick walled macroconidia

Front 49

epidermophytan

Back 49

can infect skin or nails, no microconidia and thin walled macroconidia

Front 50

2 causes of onochomycosis

Back 50

Scopulariopsis brevicaulis is mold and Candida is yeast

Front 51

organism causing impetigo

Back 51

group A strep (pyogenes), sometimes staph aureus

Front 52

organism causing bullous impetigo

Back 52

specific type of staph aureus

Front 53

oragnism causing erysipelas

Back 53

group A strep

Front 54

organism causing folliculitis (2)

Back 54

usually staph aureus, p. aeruoginosa in hot tubs/pools

Front 55

organisms causing cellulitis

Back 55

group A strep or staph aureus

Front 56

absecess in IV drug user (4)

Back 56

staph aureus, strep, gram - enterics, anaerobes

Front 57

abscess in normal

Back 57

staph aureus

Front 58

organism causing erysipeloid

Back 58

Erysipelothrix rhusiopathiae

Front 59

scabies organism

Back 59

sarcotpes scabiei

Front 60

molecules that make up tonofilaments in basal keratonocytes

Back 60

cytokeratins 5 and 14

Front 61

components of anchoring filaments

Back 61

laminin 5 and type 17 collagen

Front 62

component of anchoring fibrils

Back 62

type 7 collagen

Front 63

type 17 collagen (other name, location)

Back 63

BP antigen 2/180, has a small part which binds the hemidesmosome and the rest sticks out (the collagenous part) in the upper lamina lucida

Front 64

BP antigen 1

Back 64

230, totally within the interior of keratinocytes, near where the tonofilaments converge on the hemidesmosomes

Front 65

a3b1 intigrin

Back 65

binds both laminin 1 and 5 and collagens

Front 66

a6b4 integrin

Back 66

binds laminin 5, stabalizes hemidesmosomes

Front 67

laminin 1

Back 67

cross shaped with globular molecules; attaches to basal cells, type 4 collagen and heparin sulfate proteoglycan in the densa layer

Front 68

laminin 5

Back 68

component of anchring filaments

Front 69

type 4 collagen

Back 69

major component of the lamina densa, forms a lattice

Front 70

heparin sulfate PG

Back 70

protein core with lots of GAGs attached, gives BMZ negative charge

Front 71

type 7 collagen

Back 71

make up the anchoring fibrils, has middle a helix collagenous part and 2 globular ends

Front 72

JEB

Back 72

gene defects in either integrin a4b6 or laminin 5 or type 17 collagen, separation through the lamina lucida

Front 73

DEB

Back 73

gene defect in type 7 collagen, separation is below the lamina densa

Front 74

BP

Back 74

IgG against type 17 collagen and/or BP Ag 1, subepidermal blistering

Front 75

CP

Back 75

IgG against laminin 5 ot type 17 collagen

Front 76

EBA

Back 76

igG against type 7 collagen

Front 77

linear IgA bullous dermatosis

Back 77

IgA to distal portion (collagen part) of type 17 collagen

Front 78

dermatitis herpetiformis

Back 78

IgA to unid BMZ component

Front 79

PV

Back 79

IgG to desmoglien 3, localizes to deeper epidermis, mucosal

Front 80

PF

Back 80

IgG to desmoglien 1, localizes to the top of the epidermis, localized to head and neck

Front 81

nidogen

Back 81

lamina lucida compnonent, binds laminin 1 and type 4 collagen

Front 82

atopic triad

Back 82

allergic rhinitis, asthma, atopic derm

Front 83

major criteria for atopic derm

Back 83

pruritis, typical morphology and distribution, chronic or chronically relapsing course, personal or family hx of atopy

Front 84

sebum content (3)

Back 84

Tg's, squalene, cholesterol/cholesterol esters

Front 85

gene defect in familial melanoma syndrome

Back 85

CDKN2A