Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
251 Cards in this Set
- Front
- Back
|
Which cell layer of the skin do dermatophyte infxns happen in?
|
Stratum Corneum
|
|
|
True or False. It is normal to see mitoses throughout all skin layers.
|
False- only stratum basalis
|
|
|
What do we divide the dermis layer into?
|
Papillary- loose and Reticular- Dnse collagen
|
|
|
What is melanin synthesized from?
|
Tyrosine to DOPA to Melanin
|
|
|
What enzyme is responsible for melanin creation?
|
Tyrosinase
|
|
|
True or False. Whites have less melanocytes than blacks.
|
False- greater degradation and concentration in basal layer
|
|
|
What is the embryologic origin of melanocytes?
|
Neural Crest cells
|
|
|
Where in the skin layer are melanocytes located?
|
Straum basalis only- dendritic process extend outward
|
|
|
What is term for the skin lesion by tinea versicolor?
|
Macule
|
|
|
Whats the term for the skin lesion in acne vulgaris
|
Papule (<5mm)
|
|
|
Whats the term for the skin lesion in Basal Cell Carcinoma/
|
Nodule (>5mm)
|
|
|
Whats the term for the skin lesion in Psoriasis?
|
Patch (>5 mm)- raised and flat
|
|
|
What kind of skin lesions do chicken pox make?
|
Vesicles -fluid filled
|
|
|
What kind of skin lesions do Bullous Phemigoid make?
|
Bulla (>5mm)
|
|
|
Whats the difference between bulla and pustules?
|
Pustules have inflammatory cells
|
|
|
What kind of skin lesion does impetigo make?
|
Pustules have inflammatory cells
|
|
|
What skin lesion is caused by flooding of the dermis with fluid
|
Uritcaria/hives
|
|
|
What skin lesion is caused by a lot of dead kertinocytes because of abnormal keritinization?
|
Suborrheic Dermatitis - scales Dandruff
|
|
|
What is the microscopic term for increased stratum corneum?
|
Hyperkeratosis
|
|
|
What is the microscopic term for nuceli in the stratum corneum?
|
Parakeratosis
|
|
|
What are hyper and parakeratosis both in what condition?
|
Psoriasis
|
|
|
Whats the micro term for spire like projections from surface of skin (up or down)?
|
Papillomatosis- (verruca)
|
|
|
What is the micro term for loss of connection between keritinocytes?
|
Acantholysis- Phemigus
|
|
|
What are verrocous lesions on fingers and soles that are covered by scales caused by?
|
HPV- common wart
|
|
|
What is a bowl-shaped lesion with a central depression filled with keratin called?
|
Molluscum Contagiosum
|
|
|
What kind of Virus is Molluscum Contagiosum?
|
Poxvirus
|
|
|
What is in the center of the molluscum lesion depression in the kertinocytes?
|
Molluscum bodies- viral particles (scratching- self inocculation)
|
|
|
How does the body fight molluscum contagiosum?
|
Cell mediated immunity (6-9 months)
|
|
|
What syndrome is characterized by cough, a runny nose, and conjunctivitis?
|
Prodrome of measles
|
|
|
Put these in order for measles. Prodrome, maculopapular rash, Koplik spots
|
Prodrome followed by koplik spots, and lastly maculopapular rash
|
|
|
How does the maculopapular rash in measles proceed?
|
From the top down.
|
|
|
What is the maculopapular rash in measles caused by?
|
T cell attack on endothelial cells containing the virus - they die= bleeding, and rash
|
|
|
Before vaccination, what was a common cause of death my measles?
|
Encephalitis
|
|
|
What disease is known for painful postauricular lymphadenopathy, Forscheimers spots, and discrete papules/macules that last for 3 days?
|
Rubella
|
|
|
What kind of virus produces Rubella?
|
RNA togavirus- fades in 3 days
|
|
|
How long does Rubella infection persist?
|
3 day measles
|
|
|
Whats the only single-stranded DNA virus?
|
Parvovirus
|
|
|
What does parvovirus b19 cause?
|
Erythema infectiosum (5th disease)- slapped cheek syndrome
|
|
|
What does parvovirus b19 cause in ppl with chronic hemolytic disease?
|
Aplastic anemia
|
|
|
What disease does HHV6 cause?
|
Roseola Infantum
|
|
|
Whats the most common viral exanthem in kids under 2?
|
Roseola Infantum
|
|
|
What childhood disease is characterized by progresion from macules to vesciles to pustules?
|
Chicken pox (varicella)
|
|
|
What childhood disease is characterized by being infectious 1 week before the rash appears?
|
Chicken pox (varicella)
|
|
|
How long are the varicella pustules infectious for?
|
until they become crusted- (1 week before to 4-5 days after)
|
|
|
What skin disease is manifested by a prodrome of itching and radicular pain before the rash appears?
|
Zoster
|
|
|
What three viruses does he Tzanck test for?
|
HSV 1 and 2 and VZV
|
|
|
Are the vesicles of Zoster more itchy or more painful?
|
painful
|
|
|
Whats the most common post-surgical/wound infection?
|
Staph Aureus
|
|
|
Whats the most common cause for impetigo?
|
Staph Aureus
|
|
|
Whats the 2nd most common cause for impetigo?
|
Strep. Pyogenes
|
|
|
What is the treatment for staph skin infections?
|
TMP-SMX
|
|
|
What skin lesion is characterized by vesciles and pustules ruptureing to form honey-colored crusted lesions?
|
Impetigo
|
|
|
What toxin causes a sunburn like rash and hypotension via cytokine release
|
TSST-1
|
|
|
Which one is highly contagious, impeigo or cellultis?
|
Impetigo
|
|
|
What is the cause of a erythmatous rash involving the skin and tongue, that hs a sandpapery feeling and follows a throat infection?
|
Scarlet fever- toxin prodcution from strep pyogenes infection
|
|
|
Whats the difference between inpetigo and cellultis?
|
Cellulits involves dermis and subq layers, impetigo is superficial
|
|
|
Which one involves more heat and pain, cellulitis or impetigo?
|
Cellultis
|
|
|
What is the most common cause for cellulitis?
|
Strep. Pyogenes > Staph
|
|
|
Which type of leprosy is characterized by granulomas and a positive lepromin test?
|
Tuberculoid
|
|
|
Which type of leprosy is characterized by no granulomas and a negative lepromin test?
|
Lepromatous
|
|
|
Which type of leprosy involves hypopigmented lesions?
|
Tuberculoid
|
|
|
Which type of leprosy invovles lenonine like face full of nodules?
|
Lepromatous
|
|
|
Which type of leprosy involves lots of foamy macrophages and a zone of grenz(supepidermal region free of organisms)
|
Lepromatous
|
|
|
What disease is characterized by chronic inflammation of the pilosabaceous unit?
|
Acne vulgaris
|
|
|
What are the two types of acne lesions?
|
Inflammatory and non-inflammtory
|
|
|
Which type of acne is caused by plugging of the outer hair follicles by keratin?
|
Non inflammatoory
|
|
|
What type of acne is caused by increased sebum production due to androgens?
|
Inflammatory
|
|
|
What is the primary pathogen involved in inflammatory acne lesions?
|
Propionibacterium acnes
|
|
|
How does Propionibacterium acnes iritate the lesions in acne?
|
Produces fatty acids through its lipase- creating the inflammatory reaction
|
|
|
Whats the first line against acne?
|
Tetracycline
|
|
|
What is the locaiton for superficial mycoses?
|
Stratum corneum
|
|
|
True or False. Incidence of superficial mycoses occur more in cold, dry weather.
|
False- more in humid hot weather
|
|
|
Put these in order of occurrence. Tinea unguim, tinea pedis, tinea versicolor, tinea cruris
|
Tinea pedis, tinea unguim, tinea versicolor, and tinea cruris (jock itch)
|
|
|
What area of the body is most often affected by trichophyton tonsurans?
|
Scalp- tinea capitis
|
|
|
What device detects flourescent metabolitses produced by organisms in the skin?
|
Woods lamp
|
|
|
What preparation is used to detect hyphae in the stratum corneum and hari shafts?
|
KOH
|
|
|
What disease is characterized by ring shaped patches of hair loss with black dots where the hair is gone?
|
Tinea Capitis
|
|
|
What is the treatment for tinea capitis?
|
Allylamines like Terbinafine
|
|
|
Whats the mechanisms for terbinafine?
|
Inhibits squalene epoxidase- step in ergesterol synthesis
|
|
|
What does Trichophyton tonsurans mostly cause?
|
Tinea Capitis
|
|
|
What are most fungal tinea's caused by?
|
Trichophyton Rubrum
|
|
|
What does Trichophyton Rubrum cause?
|
Most superficial dermatomycoses
|
|
|
Which dermatomycoses is charachetized by annular rash w. central clearing?
|
Tinea corpis
|
|
|
Which dermatomycoses may have exposure to a cat or dog?
|
Tinea corpis
|
|
|
What is tinea corpis most often caused by?
|
Trichophyton Rubrum
|
|
|
Whats the most common site for superficial dermatomycoses?
|
Tinea pedis
|
|
|
What two types of tinea are characterized by excessive sweating?
|
Tinea cruris and tinea pedis
|
|
|
Of the tinea pedis, cruris, ungium and corporis, which one does not respond to topical agents?
|
Tinea Unguim - Nail infxn
|
|
|
What is Tinea Versicolor caused by?
|
M. Furfur
|
|
|
What type of superficial skin infxn is characterized by either hypo or hyperpigmented skin?
|
Tinea Versi(tile)-color
|
|
|
How does M.Furfur cause hyperpigmentation in Tinea versicolor?
|
IT induces enlargment of melanosomes
|
|
|
How does M. Furfur cause hypopgimentation in tinea versicolor?
|
It inhibits tyrosinanse via its acids.
|
|
|
What organism under Koh has the classic Spagetti and meatballs apppearnce?
|
M. Furfur (dimorphic fungus)
|
|
|
Whats dandruff caused by?
|
non known- maybe pityrosporum ovale
|
|
|
What is suborrheic dematitis?
|
Dandruff
|
|
|
What are the two most common associations with Dandruff?
|
Parkinsons and AIDS
|
|
|
Where can seborrheic dermatitis occur other than the scalp?
|
Eyebrows and nasal creases- greasy dermatitis that’s also scaly
|
|
|
What disease is characterized by a linear chain of suppurative lymphocutaneous nodules?
|
Sporotrichosis
|
|
|
What is cutaneous larva migrans caused by?
|
Ancyclostoma Brazilense
|
|
|
What is the definitive host for ancyclostoma?
|
Dogs and cats poop in sandboxes
|
|
|
What is cutaneous larva migrans?
|
Larvae swim through skin and cause tunnels to form- intesnse itching
|
|
|
What does Cimex Lectularius cause?
|
Our old friend- the bedbug- allergic reaction to its saliva- it drinks your blood
|
|
|
What are liver spots or brown macules on elderly individuals on sunexposed areas?
|
Solar lentigo
|
|
|
True or False. Solar lentigo, characterized by liver spots, are precancerous.
|
False,
|
|
|
True or False. While freckles have increased melanocytes, Solar lentigo simply has more melanosomes.
|
False, other way around
|
|
|
True or false. Ephelis is characterized by an increased amount of melanosomes, not melanocytes.
|
True, freckles have more melanin, not more cells
|
|
|
True or False. Vitiligo is more common in whites than blacks.
|
False, its more common in blacks
|
|
|
What is characterized by an autoimmune destrcution of melanocytes.
|
Vitiligo (as opposed to albinism)
|
|
|
True or False. Albinism has a decreased number of melanocytes.
|
False, that’s vitiligo. Albinism has less tyrosinase leading to absence of melanin in melanocytes
|
|
|
True or False. Albinism is related to autoimmune conditions, such as Hashimotos and hypoparathyroidism
|
False, that’s vitiligo. Albinism does not have autoimmune aspect
|
|
|
What hyperpigmentation disorder is caused by pregnancy or OCP use?
|
Melasma
|
|
|
Melasma is associated with (increased/decreased) (melanocyte number/melanosome production)?
|
Increased Melanosome production
|
|
|
Nevus cells are modified (melanocytes/keritinocytes).
|
Melanocytes
|
|
|
Which type of nevus is characterized by nests of nevus cells only in basal cell layer?
|
Juncitonal nevus
|
|
|
Which type of nevus occurs in children and involves nevus cells expanding into superficial dermis?
|
Compound nevus
|
|
|
Which type of nevus is a compound nevus without its juncitonal component?
|
Intradermal nevus
|
|
|
Whats the layer term for a nevus?
|
mole
|
|
|
What type of nevus did mom have before she got them removed?
|
Intradermal nevus
|
|
|
What type of nevus do I have on my hand?
|
Junctional nevus
|
|
|
True or False. People are born with nevi.
|
False, they develop in early childhood. (I gained the ability to tell right from left)
|
|
|
Whats a nevus bigger than 6mm, on an erythematous background, with irregular borders called?
|
Dysplasticc nevus
|
|
|
True or False. Dysplastic nevi usually proceed to melanoma.
|
False, that association has not been made yet.
|
|
|
How is dysplastic nevus syndrome inherited?
|
Autosomal Dominantly
|
|
|
What dissease has more than 100 dysplastic nevi, is inherited auto-dominantly, and always progresses to melanoma?
|
Dysplastic nevus sydrome
|
|
|
Dysplastic nevus sydrome rarely proceeds to melanoma. (true/false)
|
False, many do get melanoma (yearly derm exam required)
|
|
|
Which skin cancer has the leading cause of death?
|
Melanoma
|
|
|
What is the single most important risk factor for melanoma?
|
Exposure to a lot of UV sunlight at an early age
|
|
|
What biochemical disorder predisposes to melanoma?
|
xeroderma pigmentosum (nucleotide excision repair0
|
|
|
True or False. Superficially spreading melanoma is not in the dermis at all.
|
False. It is in the papillary dermis, just hasn't broken through the reticular dermis
|
|
|
True or False. Superficially spreading melanoma is like Carcinoma in Situ.
|
False, it is already malignant. In CIS, the basement membrane is not breached. In superficially spreading, its just prevented from crossing reticular layer
|
|
|
True or False. Carcinoma in Situ and Hutchinson Freckle(lentigno Maligna) are similar.
|
Yes
|
|
|
Can radially spreading melanoma metastasize?
|
no, it must undergo verticle growth first
|
|
|
Which type of melanoma is the most common?
|
Superficially sprading
|
|
|
Which type of melanoma is most likely to appear on the face?
|
Lentigo Maligna Melanoma
|
|
|
Which type of melanoma has a precursor known as Hutchinson Freckle?
|
Lentigo Maligna Melanoma
|
|
|
Which type of melanoma has no radial phase?
|
Nodular melanoma
|
|
|
Which types of melanoma have the most poor prognosis?
|
Nodular melanoma and Acral lentiginous melanoma
|
|
|
What is the most significant prognostic factor?
|
Depth of invasion
|
|
|
What type of melanoma is likely to occur in blacks and asians?
|
Acral Lentignous Melanoma
|
|
|
Which type of melanoma is not associated with sun exposure?
|
Acral Lentignous Melanoma
|
|
|
Which type of melaonma is located on the palm sole or beneath the nail
|
Acral Lentignous Melanoma
|
|
|
What are the criteria for malignancy of melanoma?
|
ABCD- assymetry, border irregulairy, Color, and Diameter
|
|
|
Whats the treatment for melanoma?
|
Excision and prevention (sunblock)
|
|
|
Whats the tumor marker for malignant melanoma?
|
S-100
|
|
|
What is the embrological origin for melanoma?
|
Neural crest cells
|
|
|
Whats the precursor for squamous cell carnioma of the skin (sunlite associated)?
|
Actnic Keratosis
|
|
|
What is a skin lesion that is hyperkeratotic with a pearly gray-white appearance usually on dorsal surfaces?
|
Actinic Keratosis
|
|
|
Which skin malignancy is associated with pearly papules wih central craters?
|
Basal cell carcinoma
|
|
|
Which skin malignancy is likely to occur the upper lip and higher?
|
Basal cell carcinoma
|
|
|
Which skin malignancy has the lowest malignancy potential?
|
Basal cell carcinoma
|
|
|
Which skin malignancy is dependent on the stroma for growth factors?
|
Basal cell carcinoma
|
|
|
Which skin malignancy has nests of basofillic cells with pallisading nuclei cells on the periphery?
|
Basal cell carcinoma
|
|
|
Which skin malignancy has telengectesic vessels associated?
|
Basal cell carcinoma
|
|
|
Which skin malignancy is characterized by risks including both ARSENIC and sun exposure?
|
Squamous cell carcinoma
|
|
|
Which cancer is most likely after immunosuppresive therapy?
|
Squamous cell carcinoma
|
|
|
What type of theraphy has Sqamous skin cancer as its most common cancer following the therapy?
|
Immunosuppressive
|
|
|
What skin malignancy favors the lower lip?
|
Squamous cell carcinoma
|
|
|
Which skin malignancy has actinic keratosis as a premalignant lesion?
|
Squamous cell carcinoma
|
|
|
which skin malignancy is assocaited with scaly to nodular lesions (that often ulcerate)
|
Squamous cell carcinoma
|
|
|
What inherited disorder is characterized by increased cornuem, no granulosum, and hyperkeratosis?
|
Ichthyossi Vulgaris
|
|
|
How is ichthyosis vulgaris inherited?
|
Autosomal dominantly
|
|
|
Whats the most common inherited skin disorder?
|
Ichthyossi Vulgaris
|
|
|
What is a pruritic, sometimes painful rash that rapidly occurs after sun exposure not related to drugs?
|
Polymorphous light eruption (photodermatitis)
|
|
|
What type of skin conditions occur in people that usually have type I hypersensitivity allergies (hay fever)?
|
Atopic Dermatitis
|
|
|
What is a general term for dematalogical disorders characterized by three stages: 1. acute spongiotic dermatitsis 2. subacute dermatitis 3. Chronic hyperkeratotic/parakeratotic dermatitis?
|
Eczema
|
|
|
Which stage of eczema has spongiosis and no thickening and lots of lymphocytes?
|
Acute
|
|
|
Which stage of eczema has moderate thickening, moderate spongiosis, and less lymphocytes than acute?
|
Subacute
|
|
|
Which stage of eczema has hyperkeratosis and parakeratosis- lichenification?
|
Chronic
|
|
|
What lesion caused secondarily to itching leads to the same thing as chronic eczematous dermatiis?
|
Lichen Simplex Chronicus
|
|
|
What is thought to be the causative thing behind lichen simplex chronicus?
|
Nuerogenic mechnaism (they just scracth)
|
|
|
What type of hypersensitivity is contact dermatitis?
|
Type IV
|
|
|
True or False. Psoriasis has an HLA association.
|
True, it is genetically strongly linked
|
|
|
True or False. Psoriasis can follow a Streptococcal throat infection.
|
True guttate psoriasis
|
|
|
Are the lesions of psoriasis well demarcated/ or poorly defined
|
Well demarcated
|
|
|
What are the three main microscopic findings in psoriasis?
|
Hyperkeratosis, parakeratosis, and elongation of dermal rete pegs (capillaries close to surface)
|
|
|
Psoriasis is usually very itchy. (true/false)
|
no, its not usually pruritic
|
|
|
What happens when the scales in psoriasis are picked off?
|
Auspitz' sign - they bleed
|
|
|
What disease has oil staining of the nail with accumulaton of yellow debris beneathnail?
|
Psoriasis
|
|
|
Whats the mainstay of treatment in psoriasis?
|
Topical corticodsteroids
|
|
|
Whats the logic behind the treatment of psoriasis?
|
There is epidermal hyperplasia, and we want to stop that so use anything that will stop it
|
|
|
What type of infiltrate is seen in psoriasis
|
Neutrophils= munro abscesses
|
|
|
Is Psoriasis primarily TH1 or Th2 response
|
Th1
|
|
|
Is atopic dermatitis primarily Th1 or Th2 response?
|
TH2
|
|
|
When does psoriasis most commonly occur?
|
2 peaks- adolesence and at 60
|
|
|
What does sudden onset of psoriasis suspicous for?
|
HIV
|
|
|
What disease has flat topped violaceous papules?
|
Lichen planus
|
|
|
What disease is characterized by intensely itchy, purple, papules?
|
Lichen planus- Purple pruritic polygonal papules
|
|
|
What skin disorder that had oral muscosal lesions with fine net like white lesions is associated to Hepatitis C?
|
Lichen Planus (LP is all about Hep C)
|
|
|
Which disorder is characterized by itchy papules with fine netlike striae on top?
|
Lichen planus
|
|
|
Which disorder has Saw-tooth epidermal hyperplasia with granular zone of epidermis thickened in wedge shapes?
|
Lichen planus
|
|
|
What disease has a dense lympho infiltrate at dermal/epidermal border?
|
lichen planus
|
|
|
What itchy skin conditon is common in IV drug abuses?
|
Lichen planus
|
|
|
What disease is characterized by a SINGLE herald patch followed by a christmas tree distribution?
|
Pityriasis Rosea
|
|
|
whats the treatment for pityriasis rosea?
|
none- self limited problem
|
|
|
What can mimic pityriasis roseas?
|
Secondary syphillis- check palms and soles to distinguis
|
|
|
What disease triggered by infections (mycoplasma) or drugs (sulfa), cancers, and autoimmunie disease can have vesicles and bullae with a targetoid appearnce?
|
Eythema Multiforme (drugs, cancers, autoimmune disease, and infxns)
|
|
|
What immunologic reaction of the skin can have bullae and vesciles on palms and soles?
|
Erytema Multiforme
|
|
|
What is Erythema Multiforme that affectes the skin and mucous membranes and can be fatal/
|
Stevens johnson syndrome
|
|
|
What are flat, greasy, pigmented squamous proliferations with kertain filled cysts called?
|
Seborrheic Keratosis
|
|
|
What lesions look pasted on and commonly occuring benign epidermal tumors in older people?
|
Seborrheic Keratosis
|
|
|
What is the Leser-Trelat sign?
|
Rapid increase in number of seborrheic keratoses and is a phenotypic marker for Stomach adenocarcinoma
|
|
|
What skin manifestation is a sign for stomach adenocarcinoma?
|
Leser-Trelat sign- lots of new seborrheic keratoses
|
|
|
What benign epithelial tumor is rapidly growing , makes craters, and mimics well-differentiated squamous carcinoma?
|
Keratoacanthoma
|
|
|
Whats the treatment for keratoacanthoma?
|
Nothing- it usually regresses
|
|
|
What skin condition has Anti-Dna complexes deposited in the basement membrane and involves alopecian and degeneration of basal cells?
|
Cutaneous Lupus
|
|
|
What condition has immune complex deposition in the basement membrane and is photosensitive?
|
Cutaneous Lupus
|
|
|
What are the cornerstones for treating Cutaneous lupus?
|
Anti-Malarials
|
|
|
What type of hypersensitivity reacition is Phemigus Vulgaris?
|
Type II - Abs to desmogelin 3
|
|
|
What skin disease has a positive Nikolsky sign, characterized by IgG damage to desmosomes?
|
Phemigus Vulgaris
|
|
|
What potentially fatal immune skin disorder has acantholysis in the skin and oral mucosa?
|
Phemigus Vulgaris
|
|
|
What type of lesiosn does Phemigus Vulgaris have?
|
Intraepidermal Bullae - they are in the epidermis (hence more dangerous)
|
|
|
What skin disease has the basal cell layer on histology lookin like tombstone?
|
Phemigus Vulgaris
|
|
|
What does phemigus vulgaris predispose to?
|
infections due to loss of epidermis and just basal layer remains
|
|
|
Which skin disease has suprabasal vesicles?
|
Phemigus Vulgaris
|
|
|
Which skin disease has subepidermal vesicles and bullae?
|
Bullous Phemigoid
|
|
|
Whats the pathogenesis of Bullous phemigoid?
|
Antibodies to hemidesmosomes (Bullous phemigoid antigen -part of hemidemsoome complex)
|
|
|
Which has a negative Nikolsky sign, bullous phemigoid or phemigus vulgaris?
|
Bullous Phemigoid
|
|
|
What disease shows immunofloresence of skin linearly along dermis?
|
Bullous Phemigoid
|
|
|
True or false. Bullous phemigoid affects oral mucosa.
|
False, less likely -phemigus does this more. SO I guess not really false
|
|
|
What skin disorder is related to Gluten sensitivity Celiac disease?
|
Dermetitis Herpetiformis
|
|
|
What type of hypersensitivity is Dermetitis Herpetiformes?
|
Type III
|
|
|
What disease is characterized by IGA-anti-IGA deposits at tips of papilae
|
Dermetitis Herpetiformis
|
|
|
What disease is associated with subepidermal blisters and endomysial antibodies?
|
Dermetitis Herpetiformis
|
|
|
What surfaces is Dermetitis Herpetiformis often found on?
|
Scalp and extensor surfaces
|
|
|
What type of inflammatory infiltrate comes to the vesicles in Dermetits Herpetiformes?
|
Nuetrophils
|
|
|
What is an inflammatory lesion of subcutaneous fat known as?
|
Erythema nodosum
|
|
|
True or false. Erythema nodosum is painful
|
True, it is a painful raised nodule
|
|
|
Coccidiomycosis, histoplasmossi, TB, yersina, and sarcoidosis all have associatiosn with what skin disorder.
|
Erythema nodosum
|
|
|
What skin disorder is asscoiated with Diabetes Mellitus (not acanthosis nigricans)?
|
Granuloma Annulare
|
|
|
What is characterized by white painless plaques on side of tongue that cant be scraped off?
|
EBV associated Oral Hairy Leukoplakia
|
|
|
What is Oral Hairy Leukoplakia a sign of?
|
HIV positive
|
|
|
What is uriticaria mediated by?
|
Type 1 IgE mediated mast cell release of histamine
|
|
|
What are cherry hemangiomas/
|
occur over 30, bright red papules that turn brown over time
|
|
|
What do RA, monoclonal gammopathys, Seronegative spondlyoarthropathys, and UC/Chrons all have in common?
|
They can lead to pyoderma Gangrenosum
|
|
|
What is pyoderma gangrenosum?
|
Small pustule/papule that ulcerates and enlarges
|
|
|
What is pyoderma gangrenosum usually indicate?
|
underlying disease (RA, UC/Chrons, Myeloproliefative, or Seronegative Spondy)
|
|
|
Whats the immune mechanism for clearing warts?
|
T cell Driven
|
|
|
What are the first cells infected by HPV in the epidermis?
|
Basal cells
|
|
|
At what stage in the epidermis does HPV incorporate into the DNA?
|
Mid-epidermal level
|
|
|
Where does viral replication of HPV become highest?
|
In the granular layer
|
|
|
What is the key histologic feature to diagnose HPV on the skin?
|
Koliocytes
|
|
|
What is one disease in which the granular layer gets bigger?
|
Warts-
|
|
|
What are the inclusion bodeis in molluscum contagiosum called in the granular layer?
|
Henderson-Patterson bodies
|
|
|
Whats the relationship between Genital herpes and HIV?
|
Herpes increases transmission and susceptibiliy
|
|
|
Which type of UV light is most carcinogenic?
|
UVB (290-320 nm)
|
|
|
Whats the most common cancer in man?
|
Basal Cell Carcinoma of skin
|
|
|
What is acanthosis?
|
Elongations of the epidermal ridges
|
|
|
What layer of the skin does a callus affect?
|
Just the Stratum Corneum
|
|
|
What is Acanthosis Nigrans associated with?
|
Diabetes- insulin resistance and Visceral Malignancy (If it comes quick)
|
|
|
In what cases is Acanthosis Nigrans associated with Visceral malignancy?
|
in the case that it comes suddenly, spreads quickly, or involves palms and soles and Mucous membranes
|
|
|
What does Acanthosis nigracans on palms and soles or in the mouth mean?
|
Visceral (stomach, liver, or lungs) malignancy >> Insulin resistance
|
