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15 Cards in this Set
- Front
- Back
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Antispasticity |
decrease cramping and tightness |
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antispasmodic |
prevent use related muscle spasms - centrally active on brain and spinal reflex -use as adjunct, not first line |
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Baclofen |
Binds Gaba a R on presynaptic term.decrease Ca influx, decrease excitatory NT antispasticity --> Sz or renal failure |
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Diazepam |
GABA a R, enhance inhibition in the spinal cord and brain -abuse potential, PREG D, crosses placenta |
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Tizanidine |
presynaptic a-2-adrenergic, inhibit spinal motor neuron aviod ciprofloxacin (CYP1A2) - caution with renal insufficiency |
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Dantroline |
decrease Ca mediated excitation, block release channels DOC for malignant hyperthermia |
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dalfampridine |
K channel blocker, increase conduction of AP in demyelinated axons -increased risk of Sz Preg C |
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Motor nerve blocker |
Botulinum toxin type A (clostridium) -block release of ACH --> muscle disorder of the eye BEST FOR SMALL AREAS OF FOCAL SPASM CI: Preg and lactation |
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First line for painful MSK |
acetomenophen, NSAID |
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chlorzoxazone |
antispasmodic -red/orange urine Pregnancy C |
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Cyclobenzaprine |
oral, complete bind 93% protein - 5HT R antagonsit- look like cyclic antidepressant **** MOST EVIDENCE FOR EFFICACY preg B |
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metaxalone |
well absorbed elim via kidney half life 2.4 (fat diet), 9.2h (fasting) -drowsy, leukopenia, increase transaminase Preg C |
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Methocarbamol |
wide distribution - first pass hepatic metabolism -renal elim 3 days after 1st dose Black/brown/ green urine preg C--> abnormalities reported |
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Orphenadrine |
absorbed in GI, variable OD die to anticholinergic activity 20% protein binding decrease dose in older pt Preg C |
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carisoprodol |
soma -C-IV metabolized to meprobamate C III controlled substance--> phys and psych dependence DONT USE |
