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25 Cards in this Set
- Front
- Back
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PRICE |
protect, rest, ice, compress, elevate |
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who are the muscle relaxants |
centrally-acting muscle relaxants benzodiazepine (diazepam) baclofen (lioresal) tizanidone (Zanaflex) botulinum toxin |
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what is the centrally-acting drug |
cyclobenzaprine |
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ADR of cyclobenzaprine |
serotonin syndrome if mixed with SSRI, SNRI, or tramadol cardiac like tricyclic antidepressants
do NOT mix with alcohol or other drugs careful with even milk hepatic impairment |
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dose for flexeril |
5mg TID max 10mg TID watch dosing in elderly |
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dose for Soma |
250-350mg TID and at bedtime dependence syndrome seen |
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what is the benzo |
diazepam |
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MOA of benzo |
diazepam facilitates GABA action CNS |
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ADR of benzo |
diazepam sedation dependence potential |
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dosing for benzo |
diazepam 2-10mg 3-4x a day IM or IV for muscles spasm- 5-10mg |
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MOA of baclofen |
works in brain and spinal cord less sedating then diazepam |
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ADR of baclofen |
drowsiness, increased seizures withdrawal |
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dosing for baclofen |
5mg TID up to 80mg total daily |
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intrathecal pump |
baclofen avoids peripheral ADR and give smaller amt of drugs if stop pump it is a big deal resp depression, HOTN, infx, drowsiness |
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tizanidine MOA |
chemical variant of clonidine less HOTN effect pre and postsynaptic inhibition in spinal cord |
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ADR of tizanidine |
less muscle weakness as others CNS: drowsiness, dizziness HOTN, asthenia and hep toxicity |
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drug interactions of tizanidine |
fluroquinolones., pepsid, amiodorone, OC |
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MOA of botulinum toxin |
inhibition of Ach release at NMJ |
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administration of botulinum toxin |
inject into spastic muscle 5d to kick in and lasts 3-5mo |
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ADR of botulinum toxin |
local hematoma, generalized fatigue, dizziness, pain in neighboring muscles |
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drugs for MS |
oral: baclofen, tinazidine IM: baclofen, botulinum toxin |
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drugs for spinal cord injury spasticity |
oral: baclofen, tizanidine, diazepam, dantrolene IM: baclofen, botulinum toxin |
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trigeminal neuralgia |
baclofen |
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acute LBP |
baclofen |
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amytrophic lateral sclerosis |
baclofen, tizanidine |
