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9 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Major classes |
NMBDs Spasmolytics |
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Non depolarizing NMBDs |
Tubocurarine Pancuronium Metocurine Atracurium Vecuronium Mivacurium Rocuronium Doxacurium |
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Depolarizing NMBDs |
Succinylcholine- commonly used to facilitate intubation |
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ADR of NMBDs |
ADR of Tubocurarine Blocks ganglia loss of control of BP Affects muscarinic receptors loss of PS control of heart rate, tachycardia Release histamine, hypotension, bronchoconstriction and anaphylaxis |
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DDI of NMBDs |
Synergistic with inhalational anesthetics, aminoglycoside antibiotics and Ca2+ channel blockers Cholinesterase inhibitors antagonize competitive (nondepolarizing NMBDs) and enhance depolarizing NMBDs |
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What is the difference b/n muscle spasm and spasticity |
Muscle spasm results from peripheral injury to the musculoskeletal system ex due to overstretching of muscles Muscle spasticity results from damage to neurons within the CNS rather than injury to peripheral structures |
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Antispasticity drugs |
Baclofen and dantrolene |
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Baclofen |
MOA binds to GABA b receptors on presynaptic terminals of spinal interneurons Blocks gamma neuron activity For spinal spasticity and spasticity associated with MS Not useful for treating spasticity of supraspinal origin |
BB |
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Dantrolne |
MOA |
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