Signaling And Interleukins

Front 1

Flow cytometry will identify B-cells via these molecules

Back 1

CD19
CD20

Front 2

endogenous pyrogen

Back 2

IL-1

Front 3

acute phase response, synergistic with IL-1 and TNFa

Back 3

IL-6

Front 4

Secreted by macrophages. Increases IL-2 receptor synthesis by Th cells. Has cytotoxic effects.. Causes cachexia.

Back 4

TNF-alpha

Front 5

Chemokine (chemoattractant) for neutrophils and T cells

Back 5

IL-8

Front 6

Proliferation of Activated T Cells (Clonal Expansion)

Back 6

IL-2

Front 7

Induces IFN-g production from T cells (Th1 responses)proliferation of NK cells. NOT made by T cells. Secreted by B cells and macrophages.

Back 7

IL-12

Front 8

activates macrophages, induces MHC class I on somatic cells, induces MHC class II on APCs and somatic cells, NK cells, promotes cell-mediated immunity, antiviral effects

Back 8

IFN-g

Front 9

Inhibits Th1 cytokine activity

Source:
TH2 cellsCD4+CD25+ TregB cells, macrophages

Back 9

IL-10

Front 10

Anti-inflammatory. Induces class switch to IgA.

Back 10

Transforming growth factor - Beta

Front 11

Inhibits viral replication

Back 11

IFN-a IFN-b

Front 12

T and B lymphopoiesis

Back 12

IL-7

Front 13

Transcription factor activated by calcium-dependent signaling pathways. Important for cytokine gene transcription, among other targets

Back 13

NFAT

Front 14

Transcription factor involved in regulating many gene families: pro-inflammatory genes (adhesion molecules, cytokines, TNFa), survival factors (e.g. bcl-2, bax)

Back 14

NF-kB

Front 15

2 Drugs that inhibit IL-2 synthesis

Back 15

Cyclsporin
FK506 Tacrolimus

Front 16

Inactivates NF-kB. Immunosuppressive drug that effects macrophage and T-cell interaction

Back 16

Corticosteriod
Prednisone
Beclomethasone

Front 17

Antimetabolite derivative of 6-mercaptopurine that interferes with the metabolism and synthesis of nucleic acids. Toxic to proliferating lymphocytes.

Back 17

Azathioprine

Front 18

Binds mTOR a serine-threonine kinase to inhibit T-cell proliferation.

Back 18

Sirolimus

Front 19

Antibody against IL-2 receptor in T-cells

Back 19

Daclizumab

Front 20

Anti-lymphocyte antibodies

Back 20

OKT3, ATG, ALG

Front 21

Bone Marrow Transplant are associated with ...

Back 21

Posttransplant lymphoproliferative disorders often described as “opportunistic neoplasms”

Front 22

What cytokines:
Reduces viral replication
Increases MHC Class I
Activated NK Cells

Back 22

Type I Interferons (IFNa/b)

Front 23

How do Polysaccharide Conjugate Vaccines work?

Give 3 examples

Back 23

B cells recognize the polysaccharide and the protein can be processed by antigen-presenting cells and stimulate T cell responses.
(Hib, MCV4, PCV)

Front 24

Adjuvants added to vaccines will ...

Back 24

(1) prolong antigen exposure (slow release) and can (2) stimulate APC’s to express co-stimulatory molecules and secrete cytokines

Front 25

Tumors express novel antigens that could be used as potential vaccines.

Give 3 examples

Back 25

MAGE, HER2, MUC

Front 26

Cytokine Therapy for Cancers use

Back 26

TNF-alpha

Front 27

mAbs used to treat Cancers:
Non-Hodkin’s Lymphoma

Back 27

anti-CD20

Front 28

mAbs used to treat Cancers:
Chronic Lymphocytic Leukemia

Back 28

anti-CD52

Front 29

mAbs used to treat Cancers:
Colorectal

Back 29

anti-VEGF

Front 30

mAbs used to treat Cancers:
Colorectal, Head & Neck

Back 30

anti-EGFR

Front 31

Defects in lymphocyte maturation
4

Back 31

a. SCID
i. X-linked (Common gamma chain)
ii. Autosomal recessive (JAK def., ADA, Signaling defects, RAG def)

b. Btk deficiency

c. DiGeroge syndrome

d. Class I and II MHC deficiency/ TAP deficiency

Front 32

Defects in lymphocyte activation
4

Back 32

a. Hyper IgM syndrome (CD40/CD40 ligand deficiency, other molecules involved in class switch recombination)

b. Ig subclass deficiency

c. X-linked lymphoproliferative disease (SAP deficiency)

d. Familial hemophagocytic syndrome (Perforin deficiency, others causes as well)

Front 33

Immunodeficiency associated with other inherited diseases
2

Back 33

a. Wiskott-Aldrich syndrome (WASP deficiency

b. Ataxia Telangiectasia

Front 34

Diseases associated with autoimmunity
3

Back 34

a. IPEX

b. ALPS

c. AIRE (APECED)

Front 35

Defects in Innate Immunity

Back 35

Phagocytic cell function:
CGD, Chediak Higashi, Leukocyte Adhesion deficien

Complement deficiencies

Front 36

cytokine for myeloid making

Back 36

IL-3

Front 37

cytokine for platelet making

Back 37

IL-11

Front 38

cytokine for eosinophil making

Back 38

IL-5

Front 39

B-cell signal transduction complex

Back 39

IgA
IgB
CD19
CD21

Front 40

expressed during rearrangement of gene segments for synthesis of heavy chain.

Back 40

Tdt

Front 41

Lacks CD18 of Beta-chain

Back 41

Leukocyte adhesion deficiency (umbilical cord infection)

Front 42

LFA-1 binds

Back 42

ICAM-1

Front 43

CD2 binds

Back 43

LFA-3

Front 44

CD28 binds

Back 44

B7

Front 45

Th2 cells produce

Back 45

IL-2
IL-4
IL-5
IL-6
IL-10

Front 46

Deficiency of CD40L

Back 46

x-linked hyper-IgM

Front 47

deficiency of C1-INH

Back 47

Hereditary angioedema

Front 48

Nef gene

Back 48

downregulates class I MHC

Front 49

Tat gene

Back 49

inhibits cytokine synthesis in both infected and uninfected cells