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27 Cards in this Set
- Front
- Back
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acyclovir toxicity
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nephrotoxicity
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gancicyclovir toxicity
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pancytopenia, anemia
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foscarnet toxicity
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nephrotoxicity, ca and K imbalance
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cidofovir toxicity
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nephrotoxicity (give with probenecid)
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amantadine/rimantidine toxicity
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neuro sx--agitation etc
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oseltamivir toxicity
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n/v/d
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zanamivir toxicity
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contraindicated in asthma
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name of RSV monoclonal antibody
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palivizumab
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which nucleoside analogue for herpes does not require viral phosphorylation?
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cidofovir
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what is tx for CMV?
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ganciclovir; cidofovir (second line)
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what drug can you use for adenovirus in immunocompromised?
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cidofovir
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which anti-herp is not a nucleoside analogue?
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foscarnet (inorganic pyrophosphate inhibits DNA poly)
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name 3 nrtis for hepb? which one not used for HIV?
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entecavir, lamivudine, tenofovir
Entecavir not used for HIV. Lamivudine has high resistant to most HIV. |
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what HIV drug causes hyperpigmentation palms and soles?
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emtricitabine
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what's special about abacavir?
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need to check HLA typing for severe allergic rxn
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side effects tenofovir
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nephro, GI upset, farting
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what causes nail discoloration for HIV?
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zidovudine
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what are side effects of AZT/zidovudine?
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bone marrow suppression/anemia, nail discoloration, nausea
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what are the 3 nnrtis that we need to know. how they work?
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NEE
nevirapine efavirenz etravirine allosteric inhibition RT |
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what HIV drug gives you weird dreams?
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efavirenz
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which nnrti would you not use with a high CD4 count? why?
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do not use nevirapine because can cause hepatitis with high CD4
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what drug has to be injected twice a day? What does it do?
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enfuvirtide = gp41 fusion inhibitor
causes irritation at injection site |
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what drug do you not use in a CXCR4 tropic HIV?
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maraviroc, acts to block CCR5
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what's a new drug for HIV that prevents HIV from getting into host chromosome?
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raltegravir, integrase inhibitor
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what HIV drug can cause intracranial hemorrhage?
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tipranavir (protease inhibitor)
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name two drugs can use for RSV and side effects
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ribavirin = nucleotide analogue, can cause anemia and is teratogen
palivizumab = monoclonal ab, no side effects |
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name two drugs can use for Hep C and side effects
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interferon alpha (peglyated) = flu-like sx
ribavirin = nucleotide analogue, anemia, teratogen |
