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47 Cards in this Set

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  • Back
normal salicylates obtained in the diet everyday
10-200 mg
autoimmune inflammation; not from wear and tear
rheumatism
salicylates inhibit the biosynthesis of
PGE2, a mediator of inflammation and pain
peptide assoc with pain and inflammation
bradykinin
dose of salicylate required to see analgesic activity (for inflammation and musculoskeletal-type pain)
600-1200 mg
cause of heat and redness assoc with inflammation
leakage of protein
found in all sites where PGs have an action
COX I
found only in sites of inflammation, so targeted to decrease ADRs
COX II
dose of NSAID required for antopyretic activity
600 mg
how NSAIDs reduce fevers
induction of PGE2 in the temp regulating hypothalamic center
causes vasoconstriction and increases aggregation of platelets
COX I
causes vasodilation and decreases aggregation of platelets
COX II
associated with Thromboxane which causes vasoconstriction
COX I
makes vessel walls sticky allowing platelets to clog the lumen
TX
PGI2 works against __ to prevent clogging of vessels
TX
NSAIDs have a "dose-related elimination half life" which means
increased dose of NSAID increases dose of salicylic acid which is more difficult to excrete
and important factor in the CL of salicylates
urinary pH
liquid aspirin
arthropan
arthropan is aka
choline salicylate
NSAIDs have cross-sensititvity with
tetrazine dye
oral synthetic analog of PG which is used to decrease NSAID-related ulcers
Misoprostol, Cytotec
50-200 mcg qid
toxic dose of NSAID which produces respiratory depression in the medulla
10 g
associated with ASA and viral infections, so you don't give ASA to children under 16
Reyes' Syndrome
causes brain swelling, erratic behavior, coma, and maybe death; has no antidote
Reyes' Syndrome
decreases synthesis of PG but is weaker than ASA
Acetaminophen
APAP is __% less potent than ASA
20
why doesn't APAP have an anti-inflammatory effect?
peroxides, etc, won't allow it to enter inflammed tissue
why do peds normally use APAP?
is available as a liquid because more soluble than ASA (and the Reyes' thing)
toxic dose of APAP; cross-links DNA
8-10g
generates a toxic intermediate from APAP which can't be conjugated as normal by
glutathione
early sx of hepatotoxicity with APAP
n/v, cramps, jaundice
antidote for APAP tox
Mucomyst (N-acetylcysteine)
oral, 140 mg/kg
how does Mucomyst work against APAP tox?
will help conjugate the toxic intermediate
decreases viscosity of secretions with cystic fibrosis
mucomyst
may or may not be grouped as an NSAID
ASA
Ibuprofen was introduced in __ for this reason
1974, circumvent gi probs of ASA
although __ are more effective at treating arthritis and the like, why aren't they used?
steroids, like Prednisone; MANY more ADRs
why were COX II inhibitors designed?
to decrease gi problems assoc with COX I inhibitors
inducible in inflammation but also found in gi and renal sites
COX II
when you inhibit COX I and PG in mucosal cells, you __ HCL, and __ HCO3 and __ mucus
increase, decrease, and decrease
__% patients experience gi distress, ulcers, gasritis, etc. with NSAIDs
30-45
__ of every 1000 patients using NSAIDs for arthritis have serious gi event
15
constitutive housekeeping gene
COX I
Relafen, Lodine, Clinoril, and COX II selectives all have a __ GI risk
decreased
retains renal blood flow which ppl with acute renal failure rely on
COX I
thought to circumvent renal blood flow issue, but not the case
COX II
ppl who should not take NSAIDs
ppl with acute renal failure