Sfos 70

Front 1

When the secretion of ADH occurs in the absence of stimuli (osmolarity or volume) then it is a clinical manifestation grouped into what kinds of disorders?

Back 1

Inappropriate ADH syndrome (Schwartz-Barter Syndrome)

Front 2

What are the four general causes of Inappropriate ADH Syndrome?

Back 2

Hypothalamic set point changes/ or diruptions of regulations; "faulty stimuli", Other tissue secretion of ADH; Drugs that enhance secretion

Front 3

What can occur to ADH secretion during Right sided heart failure?

Back 3

ADH secretion is increased due to an apparent drop in volume ("faulty stimuli"); Volume does not actually drop but is just sequestered to the venous side.

Front 4

What is the characteristic biochemical abnormality in Inappropriate ADH syndrome?

Back 4

Hyponatremia

Front 5

What occurs to the GFR with continued water conservation seen in inappropriate ADH Syndrome?

Back 5

GFR increases

Front 6

What occurs to renin secretion with continual water conservation?

Back 6

Increased ECFV causes suppresion of renin and thus aldosterone (sodium is lost)

Front 7

What occurs to ANF during inappropriate ADH secretion?

Back 7

It rises in responses to increased ECFV and reduces aldosterone (exacerbates hyponatremia)

Front 8

Symptoms of "water intoxication" occur when the development of hypotonicity is (MORE or LESS) rapid?

Back 8

More rapid

Front 9

What are the initial symptoms of water intoxication?

Back 9

headaches, drowsiness and weakness

Front 10

What findings are suggestive of the diagnosis of inappropriate ADH syndrome?

Back 10

detectable serum ADH in the presence of serum hypo-osmolality; OR ; Serum hypo-osmolality with a hyperosmolar urine

Front 11

What can inappropriate ADH secretion be treated with IF the cause is known to be in the hypothalamus?

Back 11

Ethanol (and dilantin)

Front 12

In the treatment if inappropriate ADH secretion, what could you use if you wanted to inhibit the ADH effect at the renal tubule?

Back 12

Lithium

Front 13

What 4 clinical circumstances may lead to the inability to excrete a water load leading to serum hypo-osmolality and inappropriatly concentrated urine?

Back 13

Inappropriate ADH syndrome; Inadequate circulatory status; renal failure; adrenal failure

Front 14

Where does oxytocin have a potent effect on?

Back 14

myometrium and smooth muscle surrounding the alveoli of mammary glands

Front 15

This neuroendocrine reflex is tied into oxytocin release?

Back 15

Milk ejection reflex

Front 16

What occurs to labor if oxytocin is absent?

Back 16

labor is prolonged

Front 17

Damage to the hypothalamus will cause an increase or decrease in prolactin secretion?

Back 17

Increase (hypothalamus is normally inhibiting prolactin)

Front 18

What effect does estrogen have on milk secretion?

Back 18

Inhibits lactation (the effect of prolactin)

Front 19

The pituitary is under trophic influence of the CNS which (IS or IS NOT) carried by systemic circulation?

Back 19

It is NOT carried by systemic circulation (if u transplant the pituitary away, then it will lose function)

Front 20

Where does arterial blood to the hypothalamic plexus come from?

Back 20

superior and inferior hypophyseal arteries (from internal carotid)

Front 21

Where does venus blood from the hypothalamic plexus drain to ?

Back 21

petrosal sinus

Front 22

Prolactin inhibiting Factor is sturcturally similar to this hormone which also inhibits prolactin release?

Back 22

Dopamine

Front 23

Antipsychotic drugs often cause this side effect on pituitary function by blocking dopamine receptors?

Back 23

hyperprolactinemia

Front 24

Negative feedback by a target gland hormone is an example of (long loop or short loop ) negative feedback?

Back 24

Long loop negative feedback

Front 25

Negative feedback by a pituitary hormone acting back on the brain to cause its own secretion to be reduced is an example of (short-loop or long loop) ?

Back 25

Short loop

Front 26

What are the 7 hypothalamic hormones identified?

Back 26

TRH, GnRH, SRIF, GRH, CRH, PIF, GAP

Front 27

The hypothalamic hormones are all (steroid or peptide) hormones?

Back 27

Peptide

Front 28

What can antipsychotic drugs cause which block dopamine. This is a side effect on the pituitary?

Back 28

Hyperprolactinemia

Front 29

Neuroendocrine transducers do what?

Back 29

transduce electrical signals into hormonal signals

Front 30

A pituitary hormone acting back on the brain to cause its own secretion to be reduced is a form of (long-loop or short-loop negative feedback)

Back 30

Short-loop