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27 Cards in this Set
- Front
- Back
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where does crossing over in paired chromosomes
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pseudoautosomal regions (PAR) (located adjacent to SRY)
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autosomal genes assx with sexual differentiation
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SF-1
SOX-9 Wt-1 |
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X chromosome genes assx with sexual differentiation
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DAX-1
androgen receptor |
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Y chromosome genes assx with sexual differentiation
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SRY
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forms the mullerian duct (females)
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paramesonephric duct
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forms the wolffian duct (males)
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mesonephric duct
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gene that is responsible for development of sertoli cells
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SOX-9
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gene that turns on SOX-9
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SRY
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sertoli cells secrete what that causes regression of mullerian ducts
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AMH (anti-mullerian hormone)
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important for maintenance and production of wolffian duct
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testosterone
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gene produced by leydig cells that causes testicular descent
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INSL-3
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order of genes in male development
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SRY
SOX-1 AMH INSL-3 testosterone |
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gene secreted by sertoli cells that causes leydig cell differentiation
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DHH (desert hedgehog)
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stimulates mesonephric coelomic cells to migrate to genital ridge and form seminiferous tubules of testes
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sertoli cells
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gene that is blocked by sertoli cells that then allows continued mitosis of sperm cells
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Stra-8 (blocked by CYP26B1)
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gene critical for female development (initiates cascade)
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R-SPONDIN
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gene that blocks SOX-9 expression in females
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b-catenin
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genes activated by Wnt4 in females
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b-catenin
DAX-1 |
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gene activated by R-SPONDIN in females
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Wnt-4
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gene that blocks expression of steroidogenic enzymes in females
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Wnt-4
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blocks AMH in the female
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DAX-1
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two phases of testicular descent
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transabdominal (INSL-3)
inguinoscrotal (AMH) |
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cryptochordism increases risk for what
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testicular cancer
infertility |
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abnormal opening of penile urethra on ventral side of penis
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hypospadias
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increased exposure to what increases risk for hypospadias
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estrogen
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failure of descent of testes
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cryptochordism
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origin of clitoris/penis
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genital tubercle
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