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11 Cards in this Set
- Front
- Back
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Drugs in NRTIs
moa |
didanosine
lamivudine tenofovir zidovudine emtricitabiine becomes phosphorylated and incorporates into DNA to block RT |
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What is the recommended ART therapy?
how many NRTI, NNRTIs, etc |
2 NRTI + (1 NNRTI or 1 boosted protease inhibitor or 1 integrase inhibitor or CCR5 antagonist)
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what is the ART therapy for preggo?
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lopinavir + zidovudine + lamivudine
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what drugs block folate synthesis?
what enzyme is blocked? |
sulfa drugs: sulfamethoxazole, sulfadiazine, sulfasoxazole, dapsone
blocks dihydropteroate synthetase |
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DOC for histoplasmosis
when is it administered in HIV patients |
itraconazole
CD4 count is < or equal to 150 and live in endemic area (central and eastern US) |
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What protein synthesis inhibitors bind to 50s and 30s
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50s - CEC
chloramphenical, erythromycin, clindamycin 30s - TA tetracycline, aminoglycosides |
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DOC of mycoplasma pneumoniae
MOA side effects |
erythromycin (macrolide)
blocks translocation torsades |
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what do pyrimethamine, trimethoprim, all sulfa drugs, and dapsone have in common?
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All are anti-folates, inhibitors of DNA replication
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what is 5-FU ?
uses? |
DNA replication inhibitor, pyrimidine analog, inhibit thymidine synthesis.
used for slow-growing tumors like breast, colorectal, and gastric tumors. |
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what is doxorubicin?
MOA |
antibiotic cytotoxin
1)creates radical oxygen species that cause DNA breaks 2)intercalates between base pairs to impair function 3)binds to plasma membrane to decrease IP3 transport |
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two main MOA of actinomycin
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1) antibiotic cytosin to inhibit DNA replication at HIGH dose
2) Transcription inhibitor at LOW dose. Used in ALL and lymphoma, breast and lung cancer |
