Session 3 Pharm -10- Protein Synthesis Inhibitors 2

Front 1

What type of drug is Gemifloxacin (Factive)

Back 1

Fluoroquinolone (DNA synthesis inhibitor)

Front 2

What type of drug is Moxifloxacin (Avelox)

Back 2

Fluoroquinolone (DNA synthesis inhibitor)

Front 3

What type of drug is Levofloxacin (Levaquin)

Back 3

Fluoroquinolone (DNA synthesis inhibitor)

Front 4

What type of drug is Ciprofloxacin (Cipro)

Back 4

Fluoroquinolone (DNA synthesis inhibitor)

Front 5

What type of drug is Ofloxacin (Floxin)

Back 5

Fluoroquinolone (DNA synthesis inhibitor)

Front 6

What type of drug is Lomefloxacin (Maxaquin)

Back 6

Fluoroquinolone (DNA synthesis inhibitor)

Front 7

What type of drug is Norfloxacin (Noroxin)

Back 7

Fluoroquinolone (DNA synthesis inhibitor)

Front 8

What type of bacteria does Ciprofloxacin cover

Back 8

covers lesser and great gram negatives, 1 of 2 fluoroquinolones for pseudomonas (other is levofloxacin) and covers atypicals

Front 9

What type of coverage do you get from levofloxacin

Back 9

covers gram + (not MRSA), enterococcus faecalis and pseudomonas, some anaerobes, and the atypicals

Front 10

What region of the body is Cipro generally associated with tx

Back 10

below the waist good for UTIs, STDs

Front 11

What region of the body are the 3rd generation fluoroquinolones associated with tx

Back 11

above the waist or respiratory FQs

Front 12

What two fluoroquinolones would you not prescribe for UTIs

Back 12

moxifloxacin and Gemifloxacin

Front 13

Which Fluoroquinolone is prescribed for tx of anthrax

Back 13

Ciprofloxacin

Front 14

Do you have to adjust dosage in renally impaired pt when giving fluoroquinolones

Back 14

yes

Front 15

What education do you have to give pt about drug interactions when taking fluoroquinolones

Back 15

forms complexes with metallic ions so avoid taking them with antacids, multivitamins or food that has metals in it

Front 16

What are the major s/e of the fluoroquinolones

Back 16

Hypo/Hyperglycemia, CNS effects, cartilage damage (avoid in pregnancy), QTc prolongation, tendon rupture (elderly), Rash

Front 17

What type of drug is Bactrim

Back 17

sulfamethoxazole and trimethoprim combo

Front 18

What is the place in therapy for Bactrim

Back 18

acute uncomplicated cystitis (first line), Pneumocystis jiroveci (PCP and PJP pneumonia), Also may be useful for CA and HA MRSA

Front 19

What are some of the major s/e of using Bactrim

Back 19

urticaria to anaphylaxis rxn, Rash can be mild to fatal SJS. N/V/D, myelosuppression, Hyperkalemia, increase in Scr

Front 20

What are the three regimens recommended for latent TB infection

Back 20

Isoniazid x9 months or 6 months or rifampin x4 months

Front 21

What is the tx protocol for active TB

Back 21

2 months using 4 drugs then 4-7months with 2 drugs (combinations can be varied and complicated depending on resistance)

Front 22

What type of drug is isoniazid (INH)

Back 22

major first line drug for tx of TB

Front 23

What type of drug is Rifampin (RIF)

Back 23

major first line drug for tx of TB

Front 24

What type of drug is Pyrazinamide (PZA)

Back 24

major first line drug for tx of TB

Front 25

What type of drug is Ethambutol (EMB)

Back 25

major first line drug for tx of TB

Front 26

What two drugs are special circumstance first line drugs for TB tx

Back 26

rifabutin and rifapentine

Front 27

When should you avoid giving Isoniazid (INH)

Back 27

it is metabolized by liver avoid giving in active liver disease

Front 28

What are the major s/e of Isoniazid (INH)

Back 28

Clinical hepatitis and fatal hepatitis, Peripheral Neuropathy

Front 29

What are the major s/e of rifampin

Back 29

hepatotoxicity, thrombocytopenia, flu-like syndrome, rash, orange discoloration of bodily fluids (tell pt may stain cloths and contact lenses)

Front 30

What are the major s/e of pyrazinamide

Back 30

hepatotoxicity, GI symptoms, Arthralgias/ gouty arthritis

Front 31

when is pyrazinamide contraindicated

Back 31

contraindicated in pt suffering from gout

Front 32

What are the major s/e of Ethambutol

Back 32

Retrobulbar neuritis (decreases visual abilities damage can be permanent),

Front 33

Which of the TB first line tx is not hepatotoxic

Back 33

only one is ethambutol

Front 34

Which fluoroquinolones can also be used to tx active TB

Back 34

levofloxacin, and Moxifloxacin

Front 35

Which aminoglycosides are also useful in tx of active TB

Back 35

streptomycin (used to be first-line) Amikacin/Kanamycin, Capreomycin

Front 36

What is the almost exclusive use of cycloserine

Back 36

tx of active TB

Front 37

What are the major s/e of cycloserine

Back 37

CNS effects

Front 38

What is Ethionamide used for

Back 38

tx of active TB

Front 39

what are the major s/e of Ethionamide

Back 39

GI symptoms, Hepatotoxicity, Neurotoxicity

Front 40

What are the major s/e of P-Aminosalicylic acid (PAS)

Back 40

hypothyroidism, GI symptoms, hepatotoxicity