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18 Cards in this Set
- Front
- Back
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Locations of serotonin |
ECC platelets CNS |
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Other name of serotonin |
5-HT (5-hydroxytryptamine) |
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Explain the Biosynthesis of serotonin |
.... |
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What is the precursor of serotonin |
Tryptophan |
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what is the intermediate product of tryptophan hydroxylase |
5-hydroxy-tryptophan |
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what is the enzyme responsible for metabolozing 5-HT |
MAO (monoamine oxidase) |
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what is the major fate of 5-HT? |
reuptake by SERT |
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if the serotonin goes active uptake, in the NT what is the product? |
5-HIAA (inactive form) |
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What NT does MAO-A &MAO-B metabolizes? |
MAO-A: NE, Epi, 5-HT MAO-B: Dopamine |
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where does in ECC of precursor came from? |
Diet |
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What are the effects of tryptophan in the Peripheral? |
Vascular tone Hemostasis Cell regeneration heart functions organ development intestinal motility immuno-modulation |
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What are the effects of tryptophan in the Central? |
Depression Sleep aggression food intake psychosis anxiety |
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What are the common targeted receptors? |
1A 2A/2B 1B/1D 3 4 |
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location of 5HT1A |
Presynapse |
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location if 5HT2A/2B |
Smooth Muscle - Uterine, Vascular Smooth Muscle) |
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location of 5HT1B/1D |
Peripheral Blood Vessels |
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location of 5HT3 |
Brain (area postrema of the Brain) |
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location of 5HT4 |
GIT |
