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13 Cards in this Set

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  • Back
5HT has been implicated in these disease states:
Depression, anxiety, schizo, eating disorders, OCD, migraines, and panic disorders
What are the major stores of 5HT? (4)
Enterochromaffin cells, platelets, CNS (raphe nuclei), pineal gland
How many 5HT receptor families are there?
What are 5HT 1,2, & 4-7?
What is 5HT 3?
7; Protein coupled. A 5HT gated ion channel
About how many subtypes of each family are there?
14
What is the fxn of the 5HT1 receptors?
They inhibit the release of 5HT
What is the fxn of 5HT2 receptors?
Vasoconstriction, dilates the heart muscle, CNS action
What is the fxn of the 5HT3 receptors?
They are present in the CNS vomiting center
This 5HT-1 (one) partial agonist treats anxiety and depression?
Buspir-ONE
This 5HT1D agonist is used to to "Ma's" graine (migraine)?
Sumatriptan
This 5HT2A/2C antagonist is used for migraines, depression, and schizo
Ketanserin
This 5HT3 antagonist is used in chemo and induced vomiting?
ondansetron
This 5HT4 agonist is effective in nighttime acid reflux?
Cisapride
This 5HT transporter acts as an inhibitor. It is a common tx for depression, and OCD
Fluoxetine