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26 Cards in this Set
- Front
- Back
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What is systemic inflm response syndrom (SIRS)?
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any 2 of: fever >38 or <36, HR >90, Resp >20, PCO2>32, WBC count >12000 or <4000
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What is the normal WBC count?
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4000 - 10000 / cubic cm
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What % of WBC are lymphs?
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25-33%
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What % of WBC are monocytes?
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3-7%
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What % of WBC are bands?
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3-5%
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What are band cells?
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immature neutrophils
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What % of WBC are eosinophils?
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<3%
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What % of WBC are basophils?
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0.1%
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What is a release of ptns from liver in response to stimulation w/ IL-6 from M0 and acute phase ptns from complement and coag systems?
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acute phase response
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What is SIRS due to infection?
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sepsis
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What is sepsis w/ organ dysfunction?
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severe sepsis
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What is organ impairment 2ary to SIRS
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multi-organ dysfunction syndrome
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What is an infection-induced hyptotensive response and unresponsive to IV fluids called?
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septic shock
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What is systemic activation of clotting system followed by depletion of clotting factors and hemorrhage?
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disseminated intravascular coag (DIC)
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What is an unregulated anti-inflm response leading to immune suppression and inc risk of inf
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compensatory anti-inflm response syndrome (CARS)
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What is inflm injury to lungs leading to inflm mediators causing vascular permeability, fluid ptn and neutrophils leaving capillaries -> hypoxia and bilateral infiltrate?
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acute respiratory distress syndrome
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What part of LPS interacts w/ what part of immune response?
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TLR4 on M0 binds Lipid A
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What is the immune response to LPS on g- bacteria?
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produce inflm mediators TNF alpha and IL-1, costimulatory molcs for adaptive response, and tissue factor
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What happens if there is an overproduction of immune mediators in response to LPS?
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septic shock and DIC
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What is neg outcome of TNF-alpha?
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vasc permeability, upregulation of adhesion molcs, epression of tissue factor on endothelium
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What is neg outcome of IL-1?
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fever
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What is neg outcome of IL-6?
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acute phase ptns
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What is neg outcome of PAI-1?
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plasminogen activator inhibitor inhibits breakdown of clots
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What if neg effect of C3a and C5a binding phagocyte?
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causes phag to produce chemokines, TNF, histamine, leukotriene, prostaglandin, cytokines
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What is effect of excessive production of C5a?
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lethal bacteremia, MODS, DIC, immunodef'y
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What is pathogensis of DIC?
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endotoxin causes TNF and IL-6 to be made; excess thrombin; impaired organ perfusion -> organ damage fibrinolysis -> excess bld -> inc vasc permeability
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