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20 Cards in this Set
- Front
- Back
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Bacteremia
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Bacteria in blood
Consequences range from nothing to sepsis |
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SIRS
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Fever, tachycardia, tachypnea
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Sepsis
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SIRS + confirmed infections
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Sever sepsis
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SIRS + hypotension corrected by IV fluids
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Septic shock
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SIRS + persistant hypotension
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Multi-organ disfunction syndrome
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Organ dysfunction + everything else
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Gram positive trigger
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Lipoteichoic acid
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Gram negative trigger
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LPS
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Host
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Healthy hosts at risk of infections that cause sepsis
Patients with disruption of barrier or obstruction Immune defects |
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Immune defects
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Asplenia - capsule
Neutropenia Ab deficiency - capsule |
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Epidemic infections
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Meningococcemia, hemorrhagic fevers, plague
Also sporadic |
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Interaction of LPS with host cells
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Endothelial damage and leaky blood vessels
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Symptoms
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Fever, chills restless
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Signs
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Fever, tachypnea (low pH), confused
Disseminated intervascular coagulation -Start as petechiae |
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Diagnosis
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Clinically
Acidosis Hypotension DIC |
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Diagnosis of organism
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Gram stain
Culture |
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Treatment
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Physiologic support most important
Fluids Bicarb Increase oxygenation Maintain cardiac function |
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Empiric treatment
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Vanco and zosyn
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Decrease effect of mediators
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Hasn't worked
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Prevention
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Immunization
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