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Definition of

SEPSIS

SEVERE SEPSIS

SEPTIC SHOCK
Sepsis - SIRS with likely infective cause

Severe Sepsis - Sepsis with organ failure/dysfunction eg oliguria, lactic acidsosis, mental status change

Septic shock- Hypotension that does not respond to fluid replacement
DEFINITION OF SIRS
Systemic inflammtory response manifested by 2 or more of:

RR >20 or CO2 <32
HR >90
Temp >38 or <36
WCC >12 or <4 (or >10% immature band forms)
Sepsis investigations
septic screen: blood cultures x2, urtine culture, suptum/tracheal asp culture, wound swab

bloods: FBC eLFTs Coags ABG glucose

CXR & AXR

?CT (esp if brain/abdo source suspected)

?LP

?nasopharyngeal swab for viruses eg H1N1, SARS

?MRI if severe back pain
What is the most common cause of bilateral empyema?
acute bacterial mediastinitis
LOW YIELD INTEREST

Respiratory complications of infectious mononucleosis are uncommon. - what are some
-upper airway obstruction from tonsillar enlargement or a pharyngeal abscess,
-bilateral hilar adenopathy,
-exudative pleural effusions,
- interstitial pneumonitis,
- superimposed bacterial pneumonia
- septic thrombophlebitis +/-emboli.

A patient can develop bilateral anaerobic empyema as complication of infectious mononucleosis through two potential mechanisms, both requiring the initial development of a pharyngeal abscess. Patients can develop septic thrombophlebitis of the jugular veins resulting in septic emboli (LeMierre’s syndrome) or the abscess can invade the space between the alar and the prevertebral fasciae of the neck into a space known as “the danger space”. Once an infection enters this danger space, it has direct access into the mediastinum, resulting in mediastinitis.6 Only 2 cases of EBV-related descending necrotizing mediastinitis have been reported in the literature