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10 Cards in this Set

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What percentage of people die with sepsis once diagnosed each year in the US?
30-50%
This is the circulating WBC responsible for releasing proinflammatory and procoagulant factors when stimulated by tissue released cytokines in sepsis
monocyte (also macrophage in tissue)
Necessary endogenous compound for activation of protein C, down regulated in sepsis
thrombomodulin
This syndrome is required along with a severe infection to correctly diagnose sepsis
SIRS - Systemic Inflammatory Response Syndrome
Low dosages of this compound can prove useful in treating septic shock when traditional vasopressive inotropes prove inadequate
Vasopressin (ADH)
In patients with sepsis and hypotension, we should first initiate this therapeutic strategy
Fluid therapy (fluid challenge)
As sepsis progresses and becomes more severe, the patient will manifest this syndrome, which may lead evetually to shock and death.
MODS Multiple organ dysfunction syndrome
The three physiologic systems always affected in sepsis, which actually progresses the pathology, include:
Inflammatory system,
coagulantion system,
and fibrinolytic systems
IN certain disorders including sepsis, both bleeding and coagulation can occur concurrently. This is known as:
DIC Disseminated Intravascular Coagulopathy
CHAOS in sepsis refers to an imbalance in immunity, inflammation, and coagulation. What does the A stand for in CHAOS?
Apoptosis, as blood cells are consumed, apoptosis is accelerated to generate youthful WBCs. However, this is inadequate in sepsis