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6 Cards in this Set
- Front
- Back
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Define the Systemic Inflammatory Response Syndrome.
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Massive inflammatory reaction from systemic cytokine release.
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Define sepsis.
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Sepsis is SIRS + culture-documented infection.
Severe sepsis- organ dysfunction, hypotension/hypoperfusion. |
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What microbial structures are attributed to SIRS?
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Gram negative- lipopolysaccharide (LPS). Contains inner core, outer core, Lipid A, and O-specific antigenic polysaccharide.
Gram positive- peptidoglycan, lipoteichoic acid. Bacterial exotoxins- (all act as superantigens) Staph A- TTST Pseudomonas- Exotoxin A Fungi-mannan Strep pyogenes- M protein |
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Describe the interaction between LPS and macrophages.
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There are TLRs on the surface of monocytes and macrophages. TLR-2 recognizes cell wall fragments (gram +) and TLR-4 recognizes LPS (gram -).
LBP binds to LPS and the complex binds to CD14 on macrophages and neutrophils. These activated macs and neutrophils then release TNFa and IL-1 causing inflammation. |
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What are the two major host mediators of SIRS and sepsis?
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TNFa-central mediator
IL-1- inflammation |
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What are the three different types of shock?
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Septic, Cardiogenic, and Hypovolemic.
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