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27 Cards in this Set

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  • Back
All the enzymes of the TCA cycle are in the mitochondrial matrix, except ____, which is in the mitochondrial inner membrane.
sucinate dehydrogenase
Acetyl CoA and oxaloacetate condense, forming ____.
Citrate
Citrate is formed from the condensation of ____ and oxaloacetate, with the enzyme ____.
Acetyl CoA, citrate synthase
Citrate sythase cleaves the high energy thioester bond of _____ in the formation of Citrate.
Acetyl CoA
____ and ___ are inhibitors of citrate sythase.
ATP, Citrate
Acetyl CoA, a ___-carbon compound condenses with oxaloacetate, a __-carbon compound, to form citrate, a ___-carbon compound.
2, 4, 6
____ converts citrate into isocitrate, with cis-_____ as an intermediate.
aconitase, aconitate
Isocitrate is oxidized to ______ in the first oxidative decarboxylation reaction with the enzyme ____.
alpha- ketoglutarate, alpha- ketoglutarate dehydrogenase
Isocitrate plus ____ is oxidized to alpha- ketoglutarate, producing ____ and forming ____ and ___.
NAD+, carbon dioxide, NADH and H+
Isocitrate dehydrogenase is activated by ____ and allosterically by ____, and inhibited by _____.
NAD+, ADP, NADH
Isocitrate, a ___-carbon compound is oxidized to alpha- ketoglutarate, a __-carbon compound.
6, 5
Alpha- ketoglutarate is converted into ____, in a second oxidative decarboxylation.
succinyl CoA
Alpha- ketoglutarate plus ____ and __ is converted by alpha-ketogluarate dehydrogenase to succinyl CoA, ____,____ and ____
NAD+, CoA-SH, NADH, H+, carbon dioxide
Alpha- ketoglutarate, a ___-Carbon compound is converted by alpha- ketogluarate dehydrogenase to succinyl CoA, a ___-Carbon compound.
5, 4
Like pyruvate dehydrogenase, ______ is a multienzyme complex containing lipoic acid, ____, ____, ____, and ____.
alpha- ketoglutarate, CoASH, NAD+, FAD, thiamine pyrophosphate
Alpha- ketoglutarate dehydrgenase is inhibited by ____, ____, and ____.
succinyl- CoA, NADH, ATP
Succinyl CoA is cleaved to succinate by _____.
succinyl CoA sythetase (succinyl thiokinase)
The cleavage of the high energy _____ bond of succinyl CoA provides the substrate level phosphorylation of ____ to ____.
thioester, GDP, GTP
Succinyl CoA + GDP,Pi is cleaved to _____ by succinyl synthetase.
succinate
Succinate plus ___ is oxidized to ____ and ___, by succinate dehydrogenase.
FAD, fumarate, FADH2
Succinate transfers its 2 Hydrogens to ___, with the enzyme _____.
FAD, succinate dehydrogenase
Succinyl- CoA, Succinate, fumerate, malate, and oxaloacetate are ___-Carbon compounds.
4
___ is added to the double bond of fumarate with the enzyme ____ to produce malate.
water, fumarase
___ can be transported to the cytoplasm to initiate gluconeogenesis.
malate
Malate plus ____ with the enzyme ____ produces oxaloacetate and ____.
NAD+, malate dehydrogenase, NADH, H+
The total energy produced by one round of the TCA cycle starting with one acetyl CoA is ___ ATP.
12
___ NADH, ___ FADH2, and ___ GTP are produced by one round of the TCA cycle starting with one acetyl CoA.
3, 1, 1