Semester 1 Mini Ii Biochemistry

Front 1

All the enzymes of the TCA cycle are in the mitochondrial matrix, except ____, which is in the mitochondrial inner membrane.

Back 1

sucinate dehydrogenase

Front 2

Acetyl CoA and oxaloacetate condense, forming ____.

Back 2

Citrate

Front 3

Citrate is formed from the condensation of ____ and oxaloacetate, with the enzyme ____.

Back 3

Acetyl CoA, citrate synthase

Front 4

Citrate sythase cleaves the high energy thioester bond of _____ in the formation of Citrate.

Back 4

Acetyl CoA

Front 5

____ and ___ are inhibitors of citrate sythase.

Back 5

ATP, Citrate

Front 6

Acetyl CoA, a ___-carbon compound condenses with oxaloacetate, a __-carbon compound, to form citrate, a ___-carbon compound.

Back 6

2, 4, 6

Front 7

____ converts citrate into isocitrate, with cis-_____ as an intermediate.

Back 7

aconitase, aconitate

Front 8

Isocitrate is oxidized to ______ in the first oxidative decarboxylation reaction with the enzyme ____.

Back 8

alpha- ketoglutarate, alpha- ketoglutarate dehydrogenase

Front 9

Isocitrate plus ____ is oxidized to alpha- ketoglutarate, producing ____ and forming ____ and ___.

Back 9

NAD+, carbon dioxide, NADH and H+

Front 10

Isocitrate dehydrogenase is activated by ____ and allosterically by ____, and inhibited by _____.

Back 10

NAD+, ADP, NADH

Front 11

Isocitrate, a ___-carbon compound is oxidized to alpha- ketoglutarate, a __-carbon compound.

Back 11

6, 5

Front 12

Alpha- ketoglutarate is converted into ____, in a second oxidative decarboxylation.

Back 12

succinyl CoA

Front 13

Alpha- ketoglutarate plus ____ and __ is converted by alpha-ketogluarate dehydrogenase to succinyl CoA, ____,____ and ____

Back 13

NAD+, CoA-SH, NADH, H+, carbon dioxide

Front 14

Alpha- ketoglutarate, a ___-Carbon compound is converted by alpha- ketogluarate dehydrogenase to succinyl CoA, a ___-Carbon compound.

Back 14

5, 4

Front 15

Like pyruvate dehydrogenase, ______ is a multienzyme complex containing lipoic acid, ____, ____, ____, and ____.

Back 15

alpha- ketoglutarate, CoASH, NAD+, FAD, thiamine pyrophosphate

Front 16

Alpha- ketoglutarate dehydrgenase is inhibited by ____, ____, and ____.

Back 16

succinyl- CoA, NADH, ATP

Front 17

Succinyl CoA is cleaved to succinate by _____.

Back 17

succinyl CoA sythetase (succinyl thiokinase)

Front 18

The cleavage of the high energy _____ bond of succinyl CoA provides the substrate level phosphorylation of ____ to ____.

Back 18

thioester, GDP, GTP

Front 19

Succinyl CoA + GDP,Pi is cleaved to _____ by succinyl synthetase.

Back 19

succinate

Front 20

Succinate plus ___ is oxidized to ____ and ___, by succinate dehydrogenase.

Back 20

FAD, fumarate, FADH2

Front 21

Succinate transfers its 2 Hydrogens to ___, with the enzyme _____.

Back 21

FAD, succinate dehydrogenase

Front 22

Succinyl- CoA, Succinate, fumerate, malate, and oxaloacetate are ___-Carbon compounds.

Back 22

4

Front 23

___ is added to the double bond of fumarate with the enzyme ____ to produce malate.

Back 23

water, fumarase

Front 24

___ can be transported to the cytoplasm to initiate gluconeogenesis.

Back 24

malate

Front 25

Malate plus ____ with the enzyme ____ produces oxaloacetate and ____.

Back 25

NAD+, malate dehydrogenase, NADH, H+

Front 26

The total energy produced by one round of the TCA cycle starting with one acetyl CoA is ___ ATP.

Back 26

12

Front 27

___ NADH, ___ FADH2, and ___ GTP are produced by one round of the TCA cycle starting with one acetyl CoA.

Back 27

3, 1, 1