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12 Cards in this Set

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  • Back
The initial outgrowth of the axon from cell body and its orientation appear to be genetically determined.
Where can you find a growth cone?
At the tip of most growing neurites(axons and dendrites)
What is a growth cone?
A flattened region(lamellipodium) from which extend finger-like processes(filopodia) which are typically 5-30 um long and 0.1 um in diameter.
What is the filopodia and leading edge of lamellipodia filled with?
Fibrillar actin.
The proximal region of the growth cone is packed with
Cellular organelles.
What can be deduced when growth cones are observed in vitro?
Highly motile,dynamic structures constantly moving and exploring environment by extension and retraction of their leading edge and filopodia.
What must be present for forward mvt to occur?
Appropriate substratum onto which leading edge can attach and become stabilized.
What happens to the actin monomers at the leading edge of growth cone?
Polymerized,then swept rearward where they are depolymerized and then recycled to the leading edge where they are RE-polymerized.
Continuous cycling of actin generates
Caterpillar tread within interior of growth cone.
Actin meshwork linked to cell surface receptors(integrins,NCAMS,cadherins)
Bind to permissive susbtrate molecules(ECM molecules,laminin,fibronectin) so that meshwork remains in place.
What does axonal pathfinding involve?
Contact mediated and Diffusible
chemoattraction and chemorepulsion.
What are the molecular markers that integrin receptors on axons tips bind to?
-ECM: laminin/fibronectin
-On neurons: N-CAM
-On glia : G1-CAM