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15 Cards in this Set
- Front
- Back
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Ethosuximide
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Mech: Block the T-type Ca channel
Use: 1st line drug for absence seizures Tox: EFGHIJ -Ethosux -Fatigue -Gi prob -HA -Itch -steve Johnson syndrome |
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Benzodiazapine:
Lorazepam + diazapam |
MECH: increase in GABAa receptor
Use: First line tx acute status epilepsy Can also be used with eeclampia seizures (prefer MgSO4) Tox: Sedation and Resp Depression, tol/dep |
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PHenytonin
Fosphenytonin(parternal) |
Mech: Inactivate Na channels; 0 order kinetics
Use: 1st line for tonic seizure 1st line prophaliatic for status epi partial simple and complex Tox: SLE syndrome, increase p450, steve johnson, and tetranogen |
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Carbamazepine
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Mech: inactive Na Channel
Use: 1st line partial simple, partial complex and tonic seizure 1st line for trigeminal neuralgia Tox: Tetranogeesis, Steve johnson syndrome, increase p450 and blood dyscasia (agranulocystosis and aplastic anemia) |
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Valporic Acid
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Mech: Inactivate Na Channel in addition to inhibiting GABA transaminase hence increase in GABA conc.
Use: 1st line: tonic simple,complex partials abscense Tox: Do not use in prego (neurotube defect), GI prob |
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GABApentin
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MECH: gaba analog that inhibits high voltage Ca channels
Use: partial's simplex, complex tonic Tox: ataxia and sedation |
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Phenobarbitual
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Mech: Increase in GABAa receptor
use: partial's simple, complex and tonic Tox: Similar to benzo's Sedation, dep and tol, cardiopul depression |
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Topiramate
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Mech: Incrase GABA = block Na channel
Use: same as phenobarbitual Tox: kidney stones |
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Lamotrigine
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Mech: block Na volt channel
Use: same as phenobarbituate and absesce Tox: steve johnson. |
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Levetiracetam
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Tx: same as phenobarbitua
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tigabine
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mech: increase gaba conc by inhibit reuptake
use: partial's simple and complex |
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vigabatin
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Mech: increase gaba conc by irreversibly inhibiting GABA tarnsaminase
Use: partial's simple and complex. |
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Barbituarates
Phenobarbituate, pentobarbitual, thiopental. |
Mech: Increase in GABAa, increase DURATION of Cl channels --> decresae in neuron firing.
Use: partial's simple and complex (phenobarbituate)/ anxiety/ anathesia (thiopental) Tox: Cardioresp depression, induced p450, tol and dep, sededation (cns depression) Contra: polyphoraia repaire: with overdose. |
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Benzodiazapam
(diazapam and lorazepam) |
MECH: Increae GABAa allowing increase in FREQUENCY of Cl channels
-long 1/2 life unless you're triazolm, oxazepam, midazolam = more addictive Use: Acute status epilepsy, anxiety, general ana. Tox: resp depression (not as much as barbituate), sedation and tol/dep, increas in p450 Repari: flumazenil (antag gaba) |
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Nonbenzo hypnotics.
Zolpidem, Zaleplon, Eszoliclone |
Mech: binds to sub GABA BZ1. Short duration via liver meta
Use: insomina Tox: MOdest day after psychomotor depression, low tol and dependence. |
