Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
9 Cards in this Set
- Front
- Back
|
Benzos mechanism |
Bind GABA receptor between an alpha-1 subunit and the gamma-2 subunit
Increases frequency of Cl- channel opening |
|
|
"Z-drugs" mechanism |
Binds to BZ-1 (omega-1) receptor Appears to require an alpha-1 subunit |
|
|
Barbiturates mechanism |
Binds multiple GABA receptor isoforms Binds to a separate site than the benzos/"Z-drugs" site May block excitatory NTs Increase duration of Cl- channel opening |
|
|
Flumazenil |
Competitive antagonist for BZ binding site; blocks actions of benzos and Z-drugs
Short half-life - 30-60 minutes |
|
|
Buspirone |
5-HT1a partial agonist Not really a sedative-hypnotic but included often 2-6 weeks onset of action |
|
|
Buspirone |
Only used for anxiety Only approved for Generalized Anxiety Disorder; 2nd line tx after SSRIs/SNRIs |
|
|
Ramelteon |
Agonist at MT1 and MT2 melatonin receptors Only used for insomnia Reduce sleep latency; increase total sleep time No next day sedation or withdrawal |
|
|
MT1 receptors |
Promote onset of sleep |
|
|
MT2 receptors |
Shifts timing of circadian system |
