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5 Cards in this Set
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Phenobarbital
Secobarbital Thiopenthal Butalbital |
Mechanism: Barbiturates, increase GABA, Cl- influx w/o GABA (high dose)
Clinical Use: long T/12 = anticonvulsant (phenobarbital) short T1/2 = anesthesia (thiopental, 10 min) Side Effects: resipratory depression, CV collapse, major physical dependence, cross-tolerance with BDZ and general anesthetics |
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Ethanol
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Zero order elimination kinetics
increases GABA receptor function increase vasoconstriction and BP sleep apnea Delirium Tremens seen in withdrawal |
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Disulfiram
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"aversive therapy"
Mechanism: inhibits aldehyde dehydrogenase, leads to aversive effects of aldehyde |
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Diphenhydramine
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Antihistamine
OTC sleep aid |
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Hydroxyzine
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Antihistamine
I.M as preanesthetic (being replaced by midazolam) |
