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5 Cards in this Set

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Phenobarbital
Secobarbital
Thiopenthal
Butalbital
Mechanism: Barbiturates, increase GABA, Cl- influx w/o GABA (high dose)

Clinical Use:
long T/12 = anticonvulsant (phenobarbital)
short T1/2 = anesthesia (thiopental, 10 min)

Side Effects: resipratory depression, CV collapse, major physical dependence, cross-tolerance with BDZ and general anesthetics
Ethanol
Zero order elimination kinetics

increases GABA receptor function

increase vasoconstriction and BP
sleep apnea

Delirium Tremens seen in withdrawal
Disulfiram
"aversive therapy"
Mechanism: inhibits aldehyde dehydrogenase, leads to aversive effects of aldehyde
Diphenhydramine
Antihistamine
OTC sleep aid
Hydroxyzine
Antihistamine
I.M as preanesthetic (being replaced by midazolam)