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42 Cards in this Set
- Front
- Back
- 3rd side (hint)
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classification of sedative |
Benzodiazpine : FAT Long acting : Flurazepam Intermediate :alprazolam Short acting : Triazolam Barbiturate : Ultra short Thiopental Sgort acting Secobarbital Long acting :phenobarbitol MISC : Z DRUGS ZOLPIDEM ZALEPLON CHOLAR HYDRATE |
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drug with highest lipid solubility |
THIOPENTAL DURING ANAESTHESIA |
redistribution |
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METABOLISM OF BZD phenobarbiturate lorazepam |
active metabolite Liver enzymes Phenobarb in urine lorazepam extrahepatic conjugation zaleplon by aldehyde oxidase cyt p450 6h to chlora hydrate more |
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Addiction |
person is compelled to use it or else suffer anxiety when seperated |
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Anaesthesia |
loss of consciouness with response to absence in pain |
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Anxiolytic |
reduce anxiety |
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Dependence |
state of response to a drug when removed give unpleasant possibly lofe threathibg symptoms opp to drug effect |
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hypnosis |
sleep onduction |
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REM SLEEP |
sleep phase where day dreaming takes place |
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sedation |
red in anxiety |
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Tolerance |
red in drug effect and need incr dose for effect |
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BZD MOA |
Gaba A with 4 transmembra 5 subunits 2a1 2b2 2gamma2 between alpla1 and gama 2 bzd attach Idoform form alplha 235 facilitate inhibitory action INCREASE FREQUENCY OF CL CHANNEL OPENING LIMBOC THLMUS CEREBRAL CORTEX |
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ANTIDOTE FOR BZD |
flumazenil b carboline anxiogenic convulsant effecr INVERSE AGONIST |
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BARBITURATES MOA |
it facilitate prolongationn of inhibition of GABA GLYCINE BIND AT PLACE OTHER THAN BZD DNT ANTGNIZE BY FLUMAZENIL JUST INCREASE DURATION OF GABA MEDICSTED CL CHANEL BLOCK NA GLUTAMATE CHANNEL |
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Z DRUGS |
zolpidem zaleplon eszopiclone |
less sleep less abstein syndrome problen |
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Z drug interact with receptors |
BZ1 W1 slective hy aur ant hjy gi Alplha1 of Gaba |
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Sedation Hypnosisanesthesis mesullary depression barbiturates coma |
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sedation |
dec anxiety behavioral disibhbtion psychomotor chabges |
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Hypnosis |
DEC REM ONSET AND DURATION OF SLEEP REBOUND SLEEP CAN OCCUR ON WITHDRAWL NO LIKE SYMPTOM WITH Z DRUGS |
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anestgesia |
loss of consciousness amnesia no reflexes AMNESIA IS WD BZD BARB LIKE THIOPENTAL MIDZOLAM |
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anti convulsant |
at cost of sedation selective PHENOBARBITOL CLOZANEPAM |
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status epilipticus |
TV PHENOBARBITOL LORAZEPAM DZPM |
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nuscle relaxtant |
DZP FORCEREBRAL PALSY MEPROBAMATE MUSCLE RELAXNT |
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medualley depression |
ALCOHOL BARBITURATES |
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physiological depence lead to |
absteine syndrome |
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abstein syndrome symptim |
hyper reflxia tremor anxiety seizure |
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TOXICITY OF DIAZEPAM |
dizziness drowsiness I increase reaction time A taxia ze EPIGASTRIC DISTURBANCE P ARADOXICAL CNS EFFECT A BSTEIN SYNDROME M MEMORY LOSS |
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Clinical uses of DIAZEPAM |
diazepam d deliurium I insomnia :primary insonmia low dose for elderly Z drugs reallu good no effect sleep pattern Less Hangover *NOT FOR SLEEP APNEA ETC A ANXIETY PANI DOAORDER GEBERALIZED ANXIETY APLRAZOLAM GOOD CHOICE NOW ANTIDEPRESSANT ARE USE E EPILIPSEY P RE ANAESTHESIA MEASURMENT : LIKE THIOPENTAL DAYS SURGET DIAZOLAM BP DISORDE CLOZNAOLMA MUSCLE SPASICITY DIAZEPAM SEIZURE CLONAZEPAM WITHDRAWL MA OF ALCHOLO SEDATUVE ETX A NTI EMETIC MUSCLE RELAXANT |
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toxicity |
hangover falls fracture cognitive impairment amnesia date rape sleep driving DRUG INYERACTION WITH TTCS ANTIHISTAMINE ANT DEPRSSANT ETC |
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overdosage cx |
cvs depression reapiratory depression Tx flumenzail ventilator |
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barbiturate and carbamates |
induce liver enzymes |
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Barbiturates cx |
acute intermittent porphyria |
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chloral hydrate cx |
courmin release causing plasma protein binding site INCREASE ANTI COAGULANT |
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Busiprone |
5 HTA1 PARTIAL AGONIST ANXIOLYTIC NO CONVULSANT MUSCLE RELAXTANT EFFECT USED IN GENERAL AND ANXOETY LESS IN PANIC LESS TOLERANCE LESS REBBOUND.ANXIETY WOHDRAWL SYMP LESS |
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buaiprone metabolozed by |
CYP3 A4 ERTHYMICIN KETACNAZOLE |
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side effects of busiprone are |
pareahesia tachychardia headachr pupillary constroction GIT |
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safe for pregnancy |
BUSIPRONE |
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RAMELTON MOA |
supraciaamatic nucleus in hypothalmus activate there melatonin receptor Decrease latency of the slewp onset reound insonmia or withdrwal symotoma |
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RAMELTON BY CYP450 |
inducer decreas it concen by Eg rifampin |
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CYP1A2 CYP 2C9 |
fluvaoxmine fluconazole increase level |
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adverse effwct of RAMELTON ARE |
dizziness fatigue endocrinw hanges like TEATESTRONE LEVEL DECREASE AND PROLACTIN INCREASE TASIMELTOM |
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Orexin antagonist |
pwptide involvesin wakefulness SAVUREXANT |
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