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20 Cards in this Set
- Front
- Back
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ACH effects on Heart
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Decrease Rate, force of contraction, conduction
M-receptor activation decreases AV node conduction |
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ACH effects on Blood vessels
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Relax SM by endothelium/NO-dependent mechanism
Inhibition of NE release from adrenergic nerves |
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ACH effects on BP
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Vasodilation Decrease CO/PVR, decrease HR/contractility ---> Decrease BP
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ACH effects on GI
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Contracts GI SM
Increase Amplitude of contractions Increase peristaltic actvity ---> Increase GI motility (Diarrhea, nausea, vommit) Used for GI atony |
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ACH effects on glands
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Increase Gland secretion
Used for xerostomia Contraindicated in Peptic Ulcer |
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ACH effect on urinary tract
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Increase Urinary Peristalsis
Contracts detrusor Relaxes trigone Used for urinary retention |
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ACH effects on eye
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Causes miosis
Contracts cilliary muscle--->near vision ---> affects ability to focus. Used for reversal of mydriasis. |
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Narrow angle glaucoma
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Iris obstruction of trabecular network. Space is too narrow for humor outflow. Contract sphincter muscle of iris to fix
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Open-angle glaucoma
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Chronic/simple
Mis aligned trabecular network. Contract sphincter/cilliary muscle to re-align and fix. needs permanent drug therapy |
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Eye Drug SE
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can get into nasolacrimal duct and cause systemic absorption.
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Poor lipid soluble CHE inhibitors
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Selectivity for tissues
NMJ>ganglia>NEJ>>>>>CNS Requires higher does to effect less selective tissues |
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Lipid soluble inhibitors
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Penetrate tissues easily
No tissue selectivity |
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CHE inhibitor effect on CV system
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Decrease rate
Dilate blood vessels via vasomotor center in brain stem which decreases symp outflow Decreases BP by vasomotor center |
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CHE inhibitor effect on GI system
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Identical to cholinomimetics
actions mediated at Ganglia of Aerbach's Plexus and parasympathetic NEJ |
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CHE inhibitor effect on EYEe
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Same as cholinomimetics
Long-acting agents increase risk of cataracts if used for more than 6 months |
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CHE inhibitor action on NMJ
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Increase ACH in NMJ = increase SKM response = increase strength
Decrease Decay of ACH NMJ Given with muscarinic antagonist to decrease papar symp SE |
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Myasthenia Gravis
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Autoimmune disease where anitbodies work as competitive inhibitors of Nm and block ACH activation of NMJ
Leads to muscle weakness and fatigue Edrophonium (IV) given to dianose myasthenia gravis. If strenght increases = mg If strength decreases = no mg |
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Lambert Eaton Syndrome
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Autoimmune disease where antibodies to Ca channels required for ACH release leads to muscle weakness and fatigue
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Pralidoxime
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Cholinesterase reactivator
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Obidoxime
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Cholinesterase reactivator
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