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4 Cards in this Set
- Front
- Back
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Nutrient Influences in Gene Activity |
Ex. Vitamin D: Occurs primarily via nuclear vitmain D receptors that regulate gene transcription, calcium, phosphorus uptake and transport that affects bone status, immune function, cellular growth, and differentiation Ex. Omega 3's: Influence risk for CV disease and cancer (leading causes of death in the US) |
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Genetic Abnormalities and SNPs |
Ex. MTHFR (SNP for folate-dependent enzyme- methyl-tetrahydrofolate reductase)- affects methylation reactions Can cause increased risk for CV disease, neuropathic disorders, and specific types of cancer |
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Nutritional Influences on epigenetics |
Through DNA methyation, histone modification, and miRNA gene slicing Ex. Folate, B12, and B6 are important for DNA methylation (essential in fetal development)- also can affect susceptability to specific types of cancer through regulation of tumor suppressor genetic activity |
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Other interrelationships between nutrients and genes |
Elderly (deficient in nutrients like folate)- can produce single- and double-strand breaks in DNA, thus causing cancer |
