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53 Cards in this Set

  • Front
  • Back
Name some common upper respiratory infections
– Oronasopharynx
-- Upper Respiratory Infections, sinusitis, HSV gingivostomatitis, thrush

– Pharynx
--Pharyngitis, tonsillitis

– Larynx and Epiglottis
-- Croup, epiglottitis

– Upper trachea
Name some common LOWER respiratory infections
– Lower trachea
-- Tracheitis

– Lungs, (bronchi, bronchioles, alveoli)
--Pneumonia

–-- Bacterial-S. pneumoniae, P. cepacia, M. pneumoniae
–-- Viral-Respiratory Syncytial Virus (RSV), Influenza
–-- (Bronchitis is usually viral)

- Asthma
–- Inflammation leading to wheezing/asthma
–- Can be precipitated by allergy or infection
Respiratory Assessment
- Rate
–- Tachypnea
--- Heart or lung disease, lung infections, anemia
–- Bradypnea
--- Diabetic Keto Acidosis, liver failure, respiratory failure, ­ICP

- Rhythm

- Easy or Labored
–- Dyspnea, orthopnea, wheezing, nasal flaring, grunting, retractions

- Depth
–- Hypopnea-shallow and slow
–- Hyperpnea-increased depth and rate
Respiratory TESTING
- Pulmonary Function Tests - non-invasive
–- Vital capacity (VC)
–- Forced vital capacity (FVC)
–- Tidal volume (TV)
–- **Peak expiratory flow rate (PEFR)

- Pulse oxymetry, arterial blood gases (ABGs), apnea/bradycardia monitor (A/B)
- Chest X-ray, CT scan, MRI, bronchoscopy
Bronchoscopy
- Diagnostic or therapeutic (foreign body)

- Pre-procedure
–- Sedative / atropine
–-PT, PTT if biopsy being done

- Post-procedure
–- Suction, postural drainage
–- Fluids after gag/swallowing returns
–- Complications: hemorrhage, respiratory distress
Respiratory Assessment
Infection Considerations
- Symptoms
--Fever, cervical lymphadenopathy, sputum, erythema, bad breath

– Age
-- Maternal antibody protection
-- RSV, M. pneumoniae
-- Increased exposure with day care and school

– Size
-- Edema + secretions = bigger problems for small airways

– Decreased Resistance (ex. Cystic Fibrosis, AIDS, SLE)
-- Immune deficiencies
-- Malnutrition, anemia, fatigue

– Weakened Defenses
-- Allergies, asthma, CF
–- Seasons

- RSV (August Sept), Influenza (Winter), M. pneumonia (Fall)

- Cough
–- Timing, nature, frequency, character

- Chest pain

- Cyanosis
Addiitional Respiratory Considerations
- Infants
–- Obligate nose breathers
–- Small airways
–- Large tongues

- Older children
–- Prominent adenoids and tonsils
Respiratory Emergencies
– Upper airway obstruction - stridor
-- Epiglottitis
-- Croup
-- Foreign body aspiration

– Lower airways - cough and wheeze
-- Asthma
--Hypersensitivity reactions

– Can progress to respiratory distress
Define Respiratory Distress
- Respiratory system is not able to keep up with the oxygen and gas exchange needs of the patient.
Respiratory Distress SYMPTOMS
- Tachypnea
–- >60 infants

- Nasal flaring
–- With each breath

- Retractions
–- Substernal, intercostal

- Cyanosis
–- Decreasing SaO2

- Accessory Muscle Use
–-Neck

- Grunting
–- Collapse of vocal cords with each breath

- Mental status or speech changes
–- Restlessness
–- Confusion
Respiratory Distress Treatment
- Immediate respiratory support

- Worry about the cause once more stable
–- Oxygen
–- Medications
--- Albuterol, epinephrine

- If unable to stabilize, may need
–- Ventilation
–- Intubation
--- Nasopharyngeal or endotracheal airway
--- Tracheostomy
Definition of Respiratory Failure
• A condition resulting in failure of the lungs to function properly. This causes severe hypoxemia and/or hypercapnia.
Etiology of Respiratory Failure
– Gas exchange impairment

– Ventilation impairment
Respiratory Failure GAS EXCHANGE PROBLEMS
– Hypoxemia
-- RDS
-- High altitudes
-- Lung disease
-- Cardiac shunting
Respiratory Failure VENTILATION IMPAIRMENT
– Hypercapnia
-- Obstructive lung disease
-- Respiratory center fails to drive breathing
-- Muscles don’t allow chest expansion
Causes of Respiratory Failure
- Airway obstruction
–- Foreign body, cystic fibrosis, secretions
–- Asthma, anaphylaxis

- Lung disease
–-Severe pneumonia, asthma, cystic fibrosis, pulmonary edema, cardiac defects causing shunting from the lungs, radiation therapy

- Weakness affecting breathing
–- Drugs, severe obesity, sleep apnea

- Muscle weakness
–- Muscular Dystrophy, spinal cord injury

- Abnormal chest wall
– Injury, severe pectus excavatum, severe scoliosis
Respiratory Failure SYMPTOMS
– Restlessness (can be missed) (EARLIEST SIGN)

- Cyanosis, arrythmia

- Tachypnea, tachycardia, shortness of breath

- Mental confusion

- Headache

- Gasping for breath
-- Increased used of neck muscles

- Coma
Respiratory Failure MANAGEMENT
- Immediate respiratory support with O2

- Determine, treat underlying condition
–- Inspired humidity to decrease secretions
---Suctioning, postural drainage

– Corticosteroids for airway edema
– *Epinephrine (COMMON DRUG USED FOR RESP. FAILURE)

– Intubation
Medical use for Epinephrine for Resp. Failure
- Be careful
–- 1:1000 = 1 mg/ml used SC (Works faster than IV, ironically enough)
–- 1:10000= 0.1 mg/ml used IV

- Bronchodilator
-- 1:1000 (1mg epinephrine per ml)
-- 0.01ml/kg/dose SC
–-- maximum single dose 0.5 ml/dose
--- Repeat q 15 minutes for 3-4 doses
–--Can give q 4 h
Epinepherine Hypersensitivity Reactions
– Anaphylaxis from allergic reactions or illness
-- 1:1000
-- 0.01 mg/kg/dose IM or SC
-- 0.5mg maximum dose
-- Can repeat q 20 minutes- 4 hours

- Epi-Pen
-- > 30 kg (0.3mg per dose)

– Epi Pen Jr
--< 30 kg (0.15mg per dose)
What to monitor when Epi is given
For hypertension and tachycardia, EKG
Naloxone Use for Resp. Problems
- Opiate intoxication antidote
-- < 20 kg - 0.1 mg/kg/dose
-- > 20 kg or > 5-years - 2 mg/ dose
-- Very short acting, repeat q 2-3 minutes
-- Reevaluate diagnosis if no response after 10 mg
-- IM, IV, SC, ETT

–Side Effects
--N/V, diaphoresis, tachycardia, hypertension, tremors
Asthma Pathophysiology
- Chronic, reversible inflammatory airway disorder, involving mast cells, leukotrienes, eosinophils, characterized by
–- Airflow obstruction
--- Bronchospasm
--- Mucosal edema
--- Increased mucus production and airway remodeling
–- Airway hyperresponsiveness
--- Sensitivity to allergens
--- Often also have eczema, allergic rhinitis
Asthma MANIFESTATIONS
- Cough
–- Earliest sign, especially nocturnal
–- Dry and hacky, or productive

- Tachypnea

- Expiratory wheezing
-- Retractions

- Restlessness, anxiety, sweating

- Hunched-over, panting phrases, fatigue
Asthma Diagnostic Tests
- Pulmonary Function Tests
–- Show signs of airway obstruction
–- Low-normal or decreased vital capacity
–- Increased total lung and residual capacities

- Bronchial challenge testing

- Serum IgE levels or eosinophilia

- Chest x-ray
–- Hyperinflation of lungs, atelectasis
Four Grades of Asthma
- Intermittent
–- Symptoms twice a week or less
–- Pulmonary function > 80% normal

- Mild persistent
–- Symptoms > twice a week, but not daily
–- Pulmonary function > 80% normal

- Moderate persistent
–- Symptoms and bronchodilator use daily
–- Pulmonary function 60-80% normal

- Severe persistent
–- Symtoms continuous, activity limitations
–- Pulmonary function < 60% normal
Asthma MANAGEMENT
- Prevention
–- Identifying and avoiding triggers
---Persistent wheezing can damage lungs
-- Dust mites, animal dander, mold, cold air, foods
–- Avoiding sick contacts
–- Annual influenza immunization

- Desensitization
–-If stimuli can’t be avoided

- Medications
–- Based on severity of asthma
–- Use aided by results of Peak Flow Meter (p. 822)
Asthma Care Devices
- Spacer

- Nebulizer

- Read use of Peak Flow Meter p. 822

- Read interpreting peak flow rates p. 815

Read use of MDI p. 822
Respiratory MEDICATIONS
- Rescue Medications
–- To treat acute symptoms and exacerbations
--- Short acting ß2-Agonists
--- Oral or IV corticosteroids

- Long-Term Controller Medications (Prevention)
–- To achieve and maintain control of inflammation
--- Inhaled corticosteroids, long acting ß2-Agonists,
--- Inhaled NSAIDs, oral leukotriene modifiers
Short acting ß2-Agonists for ‘Rescue’
- Dilate smooth muscle, decreasing spasms

- Should only be taken up to four times daily

- Side effects
–- Tremors, tachycardia, insomnia, dry mouth, hypertension

- Albuterol
–- Nebulizer or MDI (spacer with MDI)
–- Oral not effective
- Xopenex (Levalbuterol HCl)
–- Nebulizer only
–-Less cardiac side effects than Albuterol
–- Can use as young as 2-years
Peak Flow Meter
Blow into it, not inhale into it
Corticosteroids for ‘Rescue’
- Decrease inflammation to treat airflow obstruction

- Lowest dose to avoid side effects
–- Osteoporosis, immune problems, hypertension

- Prednisolone (Orapred®, Pediapred®)
–- 3-10 day ‘bursts’ orally
–- 1-2 mg/kg/day divided q day to q 12 hours
–- Maximum 60 mg per day
–- Do not take with grapefruit juice
–- Orapred is 3 times more concentrated than Pediapred

- Solumedrol
–- Given IV for hospitalized patients
Long-Acting ß2 Agonists (LABA) For Control or Prevention
- Long-acting: Not for acute asthma
–- Salmeterol: Serevent® DPI
---1 puff q12h in patients > 4-years
--- Also treats exercise induced asthma (EIA)
–-Formoterol: Foradil® DPI
---Same as Salmeterol but must be > 5-years

- Combination with steroid
–- Fluticasone/Salmeterol: Advair® DPI
--- 250mcg/50mcg or 100mcg/50mcg
--- Wash mouth to decrease risk of oral candidiasis

- Tell patient to d/c ‘rescue’ bronchodilator
–- Restart only if acute exacerbation occurs
Anti-inflammatory Agents for Control
- Inhaled Corticosteroids
–- ‘Prevention of symptoms and suppression, control and reversal of inflammation’ (p. 817)
--- Flovent®
–--- Only by Discus inhaler
--- Pulmicort®
–----By inhalation or Turbuhaler®

- Cromolyn (Intal®)
–- NSAID, stabilizes mast cell membrane and inhibits inflammatory mediator release
Leukotriene Modifiers for Control
- Leukotrine Modifier

–- Prevention of bonchospasm, mucosal edema and increased secretions caused by the leukotrienes

–- Montekulast (Singulair®)
---Drug of choice
---Oral, once daily
--- No serious side effects or drug interactions

–- Zileuton and Zafirlukast
--- Dosed 2-4 times per day
---Side effects
Exercise Induced Asthma (EIA)
– Acute, self limiting
-- Onset 5-10 minutes after exercise
-- Resolves in 20-30 minutes
-- More common with endurance sports
–---Except swimming

– Avoidance of exercise unnecessary
-- Fear of exacerbation unfounded
--Socialization important
-- Long-Acting ß2 Agonists used
--- Serevent® or Foradil®
Status Asthmaticus
– Increasing distress despite treatment
–- Therapy to
--- Improve ventilation
–--- Short acting ß2-Agonists and corticosteroids
--- Re-hydrate
–---Fluids given at maintenance rate (pulmonary edema)
---If not improving, epinephrine is used
–--- 0.01ml/kg SC not to exceed 0.3ml
--- Frequent monitoring of O2, ABGs and electrolytes to assess improvement
Asthma Education
– Equipment
-- Peak flow meter, nebulizers, MDI and other inhalers, spacers

– Symptoms
-- Asthma action plan
-- Green, yellow, red zone and what to do

– Chronic steroid use
--Risk of oral candidiasis with inhaled steroids
-- decreases risk of death from asthma d/t better control
-- Need to be weaned from long term oral steroids prior to starting inhaled steroids
-- Linear growth needs to be monitored every 3-6 months
Cystic Fibrosis
- Autosomal recessive disorder of exocrine glands

- Defective CFTR gene
–- decreased secretion of chloride, increased re-absorption of sodium and water in epithelial cells
–- Results in less hydrated mucus
---Bacteria stick to it causing infection and inflammation
--- Causes thick secretions in the pancreas and in the respiratory, gastrointestinal, and reproductive tracts
--- Hard for the body to deal with and clear
Cystic Fibrosis Respiratory Effects
- Lungs normal at birth

- Recurrent infections with inflammation and viscous mucus
–- Difficult to expectorate, increased coughing
--- Daily CPT and inhaled antibiotics
–- Medium for bacterial growth, pneumonia
--- P. auriginosa, B. cepacia, S. aurues

- Structural damage of lungs

- Poor gas exchange
–- Chronic hypoxia with clubbing, hypercapnia
–- Pulmonary hypertension and respiratory failure can result

- End stage lung disease and death
–- Life expectancy is ~ 35-years
–- Males live longer
Cystic Fibrosis GASTROINTESTINAL EFFECTS
- CFRT defect  water transport to gut
–- Meconium ileus at birth can result
–- Distal intestinal obstruction syndrome (DIOS) can occur in older patients

- Pancreatic Insufficiency
–- decreased intestinal absorption

- Plus, problems with GI tract caused by CF
–- Can cause fecal impaction or intussusception
–- Adhesions can cause obstruction
-- Resection of distal ileum further decreases absorption
Cystic Fibrosis Pancreatic Insufficiency (PI)
- Pancreatic enzymes can’t reach gut or work
–- Plugging of pancreatic ducts
---Thick secretions
–-Precipitated proteins

- PI presentation
–- Greasy, bulky stools
–- FTT, poor weight gain
–- Malabsorption of vitamins A,D,E,K

- IDDM
Cystic Fibrosis HEPATIC EFFECTS
- CFTR defect leads to
–- Viscous bile
–- Clogged bile ducts
--- 15% CF patients have gallstones
–- If extensive, can lead to obstructive cirrhosis
Cystic Fibrosis FEMALE REPRODUCTIVE EFFECTS
- Females
–- Fertility maintained, but decreased
--- Viscous cervical secretions may block sperm
--- Amenorrhea 2° to severe nutritional or pulmonary problems
--- Secondary sex characteristics often delayed
Cystic Fibrosis MALE REPRODUCTIVE EFFECTS
- Males
–- Vas deferens can be absent
–- Undescended testicles can occur
Cystic Fibrosis DIAGNOSTIC TESTS
– Qualitative pilocarpine iontophoresis test
-- Measurement of chloride in the skin
-- < 40 mg is negative
--- Don’t need to re-test negative unless they have symptoms consistent with Cystic Fibrosis such as
----Family history of CF, parent is a carrier
----Bulky, foul stools, FTT, recurrent respiratory infections
---> 60 is positive but must be repeated
–---- Other disorders can cause a positive test
– Newborn Screening

-- Added to the testing September 17, 2007
Cystic Fibrosis MANAGEMENT
- Multidisciplinary approach
–- CF clinic visit recommended every 2-3 months
---Monitoring of growth and development
---Assessment of lung function with PFTs and pulse oxymetry as well as treatment
–---Pulmonary toileting with CPT or Vest bid-qid
–----Antibiotics, bronchodilators and airway clearance
--- Assessment of GI tract for malabsorption symptoms
–---Pancreatic enzyme administration
--- Monitoring for complications of treatment
--- Assessment of psychosocial issues
Cystic Fibrosis Respiratory Management
- Chest physiotherapy daily

- Mucous clearance devices

- Medications
–- Bronchodilators
–- Oxygen therapy
–- Pulmozyme aerosol to viscosity
–- Antibioitcs require much higher doses
--- Tobramycin, Gentamycin
Cystic Fibrosis POSTRURAL DRAINAGE
- Removes excess fluid and mucus

- Chronic lung disease
–- Asthma, Cystic Fibrosis (CF)
–-1-2 hours after meals
--- decreases vomiting

- More effective after aerosol or inhalation treatment

- Contraindicated:
---Pulmonary hemorrhage, pulmonary embolus, ICP, osteogenesis imperfecta
Postural Drainage AEROSOL TREATMENT
- Bronchodilators, steroids, antibiotics
–- Direct distribution into airway
–- Reduces amt of med needed
–- Avoids systemic S/E

- Nursing Implications
–- Auscultate lungs, assess response, observe for S/E
Cystic Fibrosis GASTROINTESTINAL MANAGEMENT
- Pancreatic enzymes with meals
–- Creon, Pancrease, Ultrase

- High calorie, high fat diet plus snacks
–- G-tube feeds for adequate calories

- Replace ADEK daily
Cystic Fibrosis Issues
- Psychological stress
–- Dependence / Independence struggles
–-Parental guilt
--- Sibling testing, further children, carrier state
–- Impending death of child/self
–- Support groups
Cystic Fibrosis Education
- Chest physiotherapy and postural drainage

- Proper caloric intake and diet

- Correct use and cleaning of equipment

- Early signs of infection, complications

- When to seek medical care