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5 Cards in this Set
- Front
- Back
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Amphotericin
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polyene: ergosterol-binding pore former
AE: nephrotoxicity: 1) distal tube damage 2) decreased GFR; unpleasant chills, fever, anemia DOC: cryptococcal meningitis |
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Capsofungin
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echinocandin: cell wall synthesis inhibitor via B (1,3) glucan synthase => fragile cell wall
well tolerated hepatic metabolism Useful for opportunistic AIDS infections of candida and aspergillus. NOT for pathogenic histo, coccidiomycosis, fusarium |
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Fluconazole
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azole: ergosterol deficit via inhibition of 1,4-alpha-demethylase => lanosterol surplus
readily absorbed in CSF Renal clearance Teratogenic Narrow spectrum: candida & crypto |
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Itraconazole
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azole: ergosterol deficit via inhibition of 1,4-alpha-demethylase => lanosterol surplus
poorly absorbed in CSF Liver clearance; inhibits CYP4503A Teratogenic Broad spectrum: candida, aspergillus that are resistant to Fluconazole DOC: histo, coccidioides, blasto |
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Voriconazole
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azole: ergosterol deficit via inhibition of 1,4-alpha-demethylase => lanosterol surplus
readily absorbed in CSF Liver clearance; inhibits CYP4503A Vision disturbances Teratogenic DOC: invasive aspergillus |
