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24 Cards in this Set
- Front
- Back
- 3rd side (hint)
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General Anti-viral strategies are to inhibit...
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...Viral Attachment
...Viral Enzymes ...Host expression of viral proteins ...Assembly of viral proteins ...release of virus |
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Prototype Anti-viral agent
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Acyclovir
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MOA of Acyclovir
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Viral-Static
-Converted to Acyclovir triphosphate by viral and host cell KINASES -Incorporated into DNA by viral DNA polymerase, causing DNA chain termination |
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Acyclovir is a _______ derivative that inhibits viral DNA synthesis
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Guanine
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why does Acyclovir have no affect in uninfected host cells
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host cells without virus do not have the first required kinase to modify prodrug
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What is the kinase required three times to change Acyclovir to Acyclovir triphosphate
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Thymidine kinase
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Pyrimidine nucleoside mimic
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Idoxuridine
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DOC for Genital Warts
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1º --Podofilux
(Imiquimod) |
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DOC for CMV infection in immunocompromised
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Ganciclovir
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DOC for CMV prophylaxis
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Valganciclovir
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Most bioavailable oral Guanine derivative
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Valacyclovir
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MOA of Podofilux
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Inhibits cell mitosis
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MOA of Imiquimod
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Induces mRNA encoding cytokines, including Interferon-α at site of injury
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AE of Ganciclovir
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Renal Insuf
Bone Marrow Suppression (Neutropenia, thrombocytopenia, anemia) Potentially mutagenic |
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Works by (MoA) incorporates iodine into elongating viral protein
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idoxuridine
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May work by (MoA) stimulation of interferon A at local site of application
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Imiquimod
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Synthesized and purified from the plant families Coniferae and Berberidaceae
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Podofilux
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Must be dosed at least TID
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Acyclovir
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"Is an oral prodrug
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All the oral drugs discussed are prodrugs
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Is only to be administered via the ocular route
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Idoxuridine
Trifluridine Vidarabine |
all the -ine's from this lecture
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In which AEs occur more frequently in women than men
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Podofilux
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Contraindications of Small pox vaccine
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Pregnant Women
Eczema or Atopic Dermatitis Immunosuppression Skin Conditions (burns, herpes, shingles, etc.) Allergic to vaccine components |
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Efficacy of Varicella vaccine
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Post-exposure w/in 72 hrs 70-100%
Infection 70-90% Severe dz 95% |
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When should varicella vaccine be considered in children with HIV
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CD4 of >=15%
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