Sbl - Path - Immune Injury

Front 1

Hypersensitivity involving mast cell degranulation, IGE

Reactions from mast cells are a protective mechanism against what?

What stain do you use to see mast cells?

A mosquito bite is the classic example of what?

Back 1

Type I

worm infections

toluidine blue

urticaria (hives)

Front 2

Cold urticaria involves what protein and gene?

Obstruction of sweat ducts is a cause of __________.

C1-esterase inhibitor deficiency is a cause of what?

Primary treatment for anaphylaxis?

Back 2

cryopyrin, Muckle-Wells gene

cholinergic urticaria

angioedema (urticaria of an organ)

epinephrine

Front 3

Immune injury involving Ag's on cell surface:

ABO incompatibility involves what IG?

Rh incompatibility involves what IG?

Donath-Landsteiner AB's (IGM's active in cold) are involved in what? Usually from what disease?

Back 3

Type II

IGM

IGG

Paroxysmal Cold Hemoglobinuria

syphilis

Front 4

Autoimmune attack against basement membranes - lungs, kidneys:

Autoimmune attack against desmosomes, desmoglein - epidermis falls apart:

Pernicious anemia is a defect in what?

Back 4

Goodpasture's

pemphigus

intrinsic factor

Front 5

What type of immune injury affects blood vessels, gloms, skin, and synovium?

Arthus reaction is what?

Serum sickness resulted from using serum from what animal?

Polyarteritis nodosa can result from Type III injury from what infection?

Back 5

Type III

local immune complex mediated injury

horses

Hep B

Front 6

Allograft rejection, TB skin test and fungi are all examples of what type of immune injury?

Term for altered T-cell function, seen in AIDS, sarcoid, and acute measles:

Type IV injury against melanocytes:

Back 6

Type IV

anergy

vitiligo

Front 7

"Barney Clark's disease":

What bacteria mimics axon protein and can cause nerve damage?

B-hemolytic Strep has what two major complications?

Guillain-Barre can be a complication from what infection?

Back 7

CoxSackie B

Lyme bacillus - Borellia burgdoferi

myocarditis, rheumatic fever

Campylobacter

Front 8

Thymomas can cause what disorder? Why?

Microchimerism puts you at increased risk for what?

Men have a higher risk for disorders with which HLA antigen? Women?

Back 8

Triggers cholinergic release --> myasthenia gravis

scleroderma

Men: HLA class I
Women: HLA class I(

Front 9

Which HLA is associated with ankylosing spondylitis?

Rim pattern of Auto-Ab's:

homogenous Auto-Ab's:

centromere pattern of Auto-Ab's:

nucleolar pattern of Auto-Ab's:

Back 9

HLA B27

anti-ds DNA --> SLE

anti-histones - drug-induced SLE

CREST, pulmonary HTN

anti-TH, fibrillin - scleroderma

Front 10

Hematoxylin bodies are pathognomic for what disease?

Major symptoms?

WBC nucleus without cytoplasm, with anti-nuclear Ab's:

You often see vasculitis and onion-skinning in which organ with SLE?

Back 10

SLE

arthritis, skin changes, kidney damage, fever, mental changes

LE bodby

Spleen

Front 11

What is a discoid rash?

Eponym for verrucous endocarditis in lupus:

Chronic discoid lupus involves what pathological change?

Disease with big salivary glands, bad teeth, decreased saliva:

eponym for dry eyes, dry mouth in Sjogren's:

Back 11

hairless, scaly, shiny skin

Libman-Sacks endocarditis

lymphocytes around sebaceous apparatus in skin

Sjogren's

Sicca syndrome

Front 12

Eponym for big salivary glands:

Sjogren's is common in what chronic infection?

Name for test in which you put filter paper in a person's eye to check for Sjogren's:

Sjogren's patients have increased risk of what cancer?

Back 12

Mikulicz's syndrome

Chronic Hepatitis C

Schirmer's test

B-cell lymphoma

Front 13

Diagnostic criteria for scleroderma?

Which organ has onion-skinning in scleroderma?

Where do you commonly see tight skin/sclerodactyly?

What happens to the esophagus?

Back 13

teleangiectasias on nail beds

kidneys

finger pads

"Rubber hose" esophagus - dysphagia, reflux, aspiration

Front 14

What is CREST?

Patients are at increased risk for what?

Scleroderma confined to one part of the body, seen with Lyme disease, "plastic skin":

Back 14

milder form of scleroderma - calcinosis cutis, Raynaud's, esophagitis, sclerodactyly, teleangiectasias

pulmonary HTN, primary biliary cirrhosis

morphea

Front 15

scleroderma that follows a dermatome:

Involves hemiatrophy of the face:

Two classic autoimmune paraneoplastic syndromes, can involve muscle, skin, capillaries:

Trigger point pain, no anatomical/lab correlations, usually young women, no EtOH or Valium use:

Back 15

localized linear scleroderma

Parry-Romberg

polymyositis (muscle)
dermatomyositis (skin, capillaries) - "purple eyelids, purple knuckles"

fibromyalgia