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27 Cards in this Set
- Front
- Back
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Auto-Abs against desmosomal protein desmoglein.
Dx? Hypersensitivity? |
Pemphigus
Hypersensitivity type II |
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Desmoglein 3 Auto-Abs.
Dx? Layer? |
Pemphigus Vulgaris
deep epidermis (S. Spinosom) |
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Desmoglein 1 Auto-Abs.
Dx? Layer? |
Pemphigus foliaceus
superficial epidermis(Granular layer takes the worst damage compared to Vulgaris where it is the spinous layer) |
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Pemphigus Vulgaris susceptibility linked to?
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HLA-D4 and HLA-D6
(Jewish and Mediteranian decent) |
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s/s:
Intra-epidermal bullae Superficial vesicles |
Pemphigus Vulgaris
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Tx: of Pemphigus vulgaris
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Corticosteroids
Anti-CD20 mAb (mature B cells) |
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--Auto-immune, subepidermal, blistering skin disease.
--IgG Auto-Abs against hemidesmosomal BP Ags |
Bullous Pemphigoid
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Prominent Ag involved in Bullous Pemphigoid
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BPAg2 ( > BPAg1 )
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Inflammatory cells found in blisters of someone with Bullous Pemphigoid
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Eosinophils
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Bullous Pemphigoid skin lesions express what eosinophil-specific chemokines
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Eotaxin chemokine CCL11
and IL-5 |
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In Bullous pemphigoid, this enzyme destroys the connective tissue
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Matrix metalloproteinases
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Tx of Bullous pemphigoid
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Corticosteroids
Anti-CD20 mAb (Mature B Cells) |
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Blistering of the conjuctiva and skin (occasionally)
Auto-Ags against epidermal-dermal jxn |
Mucous membrane pemphigoid
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--Blistering on elbows, knees, buttocks, and back
--Immunofluorescence of skin biopsy shows IgA deposition |
IgA Pemphigus (Dermatitis Herpetiformis)
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In IgA Pemphigus (Dermatitis Herpetiformis) against
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Epidermal Transglutaminase 3 (TGase3)
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Tx of IgA Pemphigus (Dermatitis Herpetiformis)
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Gluten free diet
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Autoimmune dz where melanocytes are destroyed
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Vitiligo
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Vitiligo is associated with what other two dzs
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Hashimoto thyroiditis
Graves dz |
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Potent inhibitors of hair growth
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TNF & IL-1
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cutaneous immune response to specific environment antigens
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Atopic dermatitis
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Cytokines that promote a switch in Ab isotope from IgM to IgE?
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IL-4 & IL-15
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Cytokine that regulates growth and regulation of eosinophils
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IL-5
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Psoriasis tx that inhibits IL-2 production
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Cyclosporin
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Psoriasis is mediated largely by CD8+ T cells. CD8+ T cells produce what chemicals?
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IFN-ɣ
Lymphotoxin TNF-ß |
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Psoriasis tx that REDUCES the number of activated T cells in the epidermis and dermis via apoptosis
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UV B or UV A + Psoralens
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Psoriasis tx:
--doesn't reduce activated T cells --Inhibits inflammation via NF-kappa B --relapse soon after cessation |
Corticosteroid
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Th2 cells produce what two cytokines that increase fibroblasts
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IL-4 and IL-13
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