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8 Cards in this Set
- Front
- Back
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Malignant cell in Hodgkin's lymphoma?
Which category has the worst prognosis? Best prognosis? Constitutional symptoms of HL? B symptoms? (paraneoplastics) |
Reed-Sternberg cell
Lymphocyte depleted - worst Nodular sclerosis - best fatigue, weakness, anorexia, cachexia, pruritus weight loss >10% body weight, drenching night sweats, unexplained fever |
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What is the test most commonly used for staging?'
Which Ann Arbor stages can be treated with radiation? Which ones are better treated with chemo? |
CT chest, abdomen, pelvis
radiation - stage I (one lymph node), II (two noncontiguous on same side of diaphragm or single organ) chemo - stage III (lymph nodes on both sides of diaphragm), stage IV (multifocal, multi organ) |
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What is mantle XRT?
What is inverted Y XRT? What drugs are in the MOPP chemo plan? MOPP is very effective in treating what stages? |
node-bearing region of thorax (neck, upper arms, sternum)
abdominal, pelvic nodes mechlorethamine, vincristine, procarbazine, prednisone Stage III, IV |
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What drugs are in the ABVD regimen?
What are some complications of chemotherapy? Primary therapy for Stage I, II HL? Primary therapy for Stage III, IV? |
doxorubicin, bleomycin, vinblastine, dacarbazine
sterility (especially with MOPP), cardiotoxicity, pulmonary, neutropenia radiotherapy chemotherapy |
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What are the three stages of lymphoma? Survival time?
Which virus causes T-cell lymphoma and leukemia? Virus associated with African Burkitt's: |
low grade (indolent) - years, intermediate (aggressive) - months, high (highly agrgressive) - weeks
HTLV-I EBV |
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When do you usually find indolent lymphoma?
Aggressive lymphoma has what type of presentation? Highly aggressive presentation? |
asymptomatic, usually incidental - may see B symptoms
waxing, waning - constitutional symptoms, splenomegaly rapid adenopathy, lesion that "came up overnight" |
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Indolent lymphoma often shows up at what stage? What about aggressive/highly aggressive?
Mandatory test for diagnosis of lymphoma: What is the CHOP regimen? |
indolent - Stage III, IV; aggressive/highly aggressive - Stage I, II
lymph node biopsy standard of care for aggressive lymphomas - cyclophosphamide, doxorubicin, vincristine, prednisone |
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Chimerized monoclonal Ab targeting CD20 on lymphocytes:
What is the mainstay of treatment for aggressive lymphoma? How are highly aggressive lymphomas usually treated? |
Rituximab (Rituxan)
combination chemotherapy ALL-style regimen |
