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41 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Squamous Cell Carcinoma risk factors
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Excessive UV exposure
Actinic Keratosis Arsenic Scar tissue in 3rdº burns Immunosuppressive therapy HPV (Hubbard) |
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Cancer on lower lip
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SCC
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V. general rule of thumb--______ prefers the lower lip
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Cancer on upper lip
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Basal Cell Carcinoma
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V. general rule of thumb--______ prefers the upper lip and higher
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Most common malignant skin tumor
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BCC
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Actinic keratosis is a precursor of what cancer
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SCC
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Cancer; Invades aggressively locally; does NOT metastisize
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BCC
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BCC arises from what cell layer
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Basal cell layer (duh!)
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Most common cancer complicating immunosuppressive therapy
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SCC
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Skin cancer; Raised papule or nodule with center crater
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BCC
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Leading cause of death due to skin cancer
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Melanoma
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Most significant risk factor for Malignant Melanoma
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Exposure to excessive sunlight as early age
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SCC arises from what cells
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Epidermal keratinocytes
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Sexual diversity stats for SCC
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M:F 3:1
Men predom |
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Tx of SCC
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Cryosurgery
surgical excision Topical Chemo (5-FU) (Large lesion) Systemic Chemo (5-FU, Cisplatin) metastatic dz for palliation |
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Tx of BCC
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Cryosurgery
Surgical Excision Mohs Surgery Electrodessication Laser Treatment |
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Tx of Nonmelanoma skin cancer recurrence
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Repeat resection
Radiation Therapy Topical Chemotherapy |
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Multiple family members have predisposition for developing melanoma.
MOI: AD |
DISPLASTIC NEVUS SYNDROME
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Skin cancer:
ABCD criteria for malignancy |
Asymmetry of shape
Border irregularity Color variation Diameter > 6mm |
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Most common type of malignant melanoma
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superficial spreading melanoma
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Type of malignant melanoma that lacks horizontal (radial) phase, thus it has sharply demarcated borders
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Nodular
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Type of malignant melanoma least likely to have vertical phase.
Elderly; on face |
Lentigo maligna melanoma
(aka Hutchinson's freckle) |
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Type of malignant melanoma:
-not related to UV exposure. -Asians & Blacks. -Palm, sole, or beneath nail |
Acral lentiginous melanoma
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Survival from malignant melanoma is directly related to ...
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thickness of the melanoma
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How much normal skin to take with the the malignant based on size of the lesion.
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How wide should the excision margin be for melanoma on the face
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1 cm for any size lesion
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Radiation therapy for malignant melanoma?
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Melanoma is considered radioresistant
Special situations: Painful bony mets brain mets |
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MOA of Interleukin (IL)-2
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Increases tumor infiltrating lymphocytes (TIL) that are directly cytotoxic to melanoma
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1º cutaneous neuroendocrine carcinoma
Arises from cells in the basal layer of epidermis and hair follicle (H) |
Merkel cell Tumor
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Looks kinda like oat cell
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Tx of Merkel cell tumors
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-Wide local excision w/ regional lymph node dissection
-Post-op radiation to site and lymph node basin -Chemo for metastatic dz |
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****Histiocytosis X:
Hand-Schuller-Christian dz characteristic triad |
Exophthalmus
Diabetes Insipidus Bony Involvement of Skull |
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Tumors of bone marrow derived dendritic cells that reside in the upper layer of the epidermis
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Tumors of Langerhans Cells
(Histiocytosis X) |
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Tumors of Langerhans Cells
(Histiocytosis X) Three diseases ? w/ age of onset? |
Letterer-Siwe Dz (<2yoa)
Hand-Schuller-Christian dz (2-6 yoa) Eosinophic Granuloma (children and young adults) |
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Ectopic sebaceous glands
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Fordyce's spots
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Tumor in the conjunctiva of the upper eye lid
women 6th-8th decade Higher in asians Slow growing but can metastisize |
Sebaceous carcinoma
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Mycosis Fungoides may occasionally shed lymphoma cells into blood. What is this called
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Sezary's syndrome
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Angiosarcoma:
--Cutaneous lymphangiosarcoma arising in chronically lymphedematous extremities --Classically seen in breast cancer |
Stewart-Treves Syndrome
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Tx of hemangioma
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WAIT--it regresses
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Pt. w/ malignant vascular lesion in the skin of lower extremities
Also has Iron def. |
Kaposi's Sarcoma that has metastisized to the GI tract
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Kaposi's Sarcoma facts:
who is most affected |
Mediterranean & Jewish elderly mean
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Kaposi's Sarcomas metastasize where
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Lungs and GI tract
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Most common of all benign soft-tissue neoplasms
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Lipoma
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