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4 Cards in this Set
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- Back
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Base unit for ABO blood typing antigens?
What is added in A, B, O antigens? What chromosome has the genes for antigen creation? Type A blood has which Ab's? B? AB? O? |
ceramide + 4 sugars (Glu-Gal-N-aga-Gal) + fucose
A - + N-acetylgalactosamine B - + galactose O - nothing chromosome 9 A: +B Ab's B: +A Ab's AB: No Ab's (universal recipient) O: +A,B Ab's (universal donor) |
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Which chromosome codes for Rh factor? Which protein is antigenic?
What happens when an Rh+ mother is exposed to an Rh- fetus? What about Rh- mother and Rh+ fetus? |
chromosome 1 - D is antigenic (C,E OK)
Rh+ mom/Rh- fetus - nothing happens (protein is absent) Rh- mom/Rh+ fetus - mom's immune system will attack baby's blood |
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How do you check blood types? What does a +agglutination test represent?
#1 cause for transfusion reactions? How do you cross match donor and recipient blood? |
use anti-serum, check for agglutination (clumping). +agglutination = Antigen present, so:
A+: +A, -B, +D B-: -A, +B, -D etc. user error mix donor's erythrocytes and recipient's plasma, look for reaction |
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Explain erythroblastosis.
What can be given to treat this? |
Rh- mother gives birth to Rh+ child. Body forms anti-Rh Ab's.
Pregnant again with Rh+ child --> strong reaction Treat with Rh- blood, or Rhogam (tricks immune system into thinking it's first exposure, so less reaction) |
