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21 Cards in this Set
- Front
- Back
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problem with FNA in diagnosing sarcoma
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does not allow for determination of histologic subtype or grade
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preferred pathologic procedure for sarcoma
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core biopsy
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Karposi's sarcoma
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low grade vascular tumor associated with HHV-8. 300x more common in AIDS and other immunocompromised
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cornerstone of soft tissue sarcoma tx
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surgery
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margin goal with surgery
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2cm margin
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radical excision definition
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5cm margin
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problem with FNA in diagnosing sarcoma
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does not allow for determination of histologic subtype or grade
|
|
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preferred pathologic procedure for sarcoma
|
core biopsy
|
|
|
Karposi's sarcoma
|
low grade vascular tumor associated with HHV-8. 300x more common in AIDS and other immunocompromised
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cornerstone of soft tissue sarcoma tx
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surgery
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margin goal with surgery
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2cm margin
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radical excision definition
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5cm margin
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excised STS with negative margins- Rad?
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NO, but if margins =<1 cm positive it may benefit from adjuvant rad
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drug of choice in STS
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doxorubicin
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single vs combo regimens in STS
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no OS benefit in combo vs single agent
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intraarterial chemo for STS?
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often cisplatin or doxorubicin used. No proven benefit over systemic tx
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primary treatment for GIST
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imatinib mesylate, which inhibits KIT
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second line therapy for GIST
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sunitinib 50mg QD x 4 weeks every 6 weeks
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treatment- STS stage Ib
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surgery +- rad +- chemo
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radiation with osteosarcoma
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osteosarcoma is resistant to radiation
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radiation with Ewings
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Ewings is more sensitive to rad
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