Sarcomas

Front 1

classification of sarcomas

Back 1

1. differentiated as 6 : fibrosarcoma, myxosarcoma, chondrosarcoma, osteosarcoma, ewing sarcoma, kaposi sarcoma.

2. undifferentiated : small and large rounded cell sarcoma, spindle and mixed cell sarcoma.

Hint 1

2 types

Front 2

discuss sarcomas

Back 2

sarcomas are malignant connective tissue tumors. they are less frequent than carcinomas. They usually affect younger age groups. They grow rapidly nd are invasive nd destructive to the surrounding tissues. Metastasis occurs through blood stream so secondary tumor growth may occur.

Hint 2

age group, metastasis and effect on surrounding tissues

Front 3

what is fibrosarcoma ?

Back 3

Malignant neoplasm of fibrous tissue.

clinically: young age. most commonly in males. occurs in: cheeks, maxillary sinus, lip, palate, gingiva and tongue.

signs: painful swelling, early facial asymmetry.
ulceration and haemorrhge.
no early metastasis.
2ndry infection are seen in some cases.

histopathology :
1. neoplastic spindle shaped fibroblasts with an elongated and deeply stained nuclei.
2. collagen fibers ( its amount depends on the amount of differentiated fibroblasts).
3. small blood vessels.

Hint 3

definition -sex - signs and symptoms - clinic.

Front 4

what is osteosarcoma ?

Back 4

ostesarcoma is a highly malignant neoplasm of bone.
most commonly is the primary neoplasm of bone but is rare overall.
* 2 types according to site :
i. intrmedullary: the most common and the most aggresive.
ii. juxta cortical : peripheral osteosrcoma (periosteal-paraosteal).

Front 5

Discuss the types of osteosarcoma.

Back 5

osteosarcoma is either
1. intramedullary ( most common and most aggressive).
2. juxta cortical: related to the outward surface of the cortex.

a. paraosteal: nodular lobule attachedto the cortex by a short stalk. it doesnt show PPR or periosteal elevation. histologically the mass shows spindle shaped fibroblast like cells with well developed bony trabecula that may fuse and form a large mass of solid bone. low grde sarcomas have a low risk of metastasis and reoccurance. this may turn into a high grade sarcoma if poorly treated [ poor prognosis].

b. periosteal: this arises within the cortex and then elevates the periosteum and forms peripheral periosteal new formed bone. the edge of the mass may perforte into the surrounding tissues. histologically : primitive sarcomtous and foci of tumor osteoid and immature bone formation. radical excision with wide margin is the ttt.

Front 6

Discuss the etiology, pathogenesis and the radiographic features of osteosrcoma

Back 6

i. Etiology (

Front 7

Discuss the clinic features of osteosarcoma.

Back 7

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