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22 Cards in this Set
- Front
- Back
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term for proteins that mediate cellular interactions and regulate cell growth and secretion (regulate many aspects of the immune system)
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cytokines
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term for family of proinflammatory and chemotactic cytokines (characteristic sequence of 4 cysteine residues)-regulate emigration of leukocytes from blood into tissues
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chemokines
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term for the cytokines that regulate the interactions b/w lymphocytes and other leukocytes
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interleukins
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term for the antiviral cytokines that are produced in response to virus infection or immune stimulation
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interferons
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macrophage and T cell derived cytokines that can exert a direct toxic effect on neoplastic cells
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Tumor necrosis factor
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are type 1 or 2 interferons assoc. w/ alpha and beta interferons (antiviral)
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type 1
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are gamma interferons type 1 or 2 interferons? (assoc. w/ immune activation)
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type 2
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TNF alpha or beta's target cell is endothelium
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alpha! (TNF-beta's target cell is tumor cells)
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growth factors generally stimulate which type of cells?
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stem cells
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which effect(autocrine, paracrine, endocrine) describes cytokines that bind to receptors on the cells that produce them?
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autocrine effect
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T/F: Il-2 acts on T cells which produce them
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T! example of autocrine effects
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term for the cytokine action in which most cytokines act on different target cell types, inducing different responses in each one
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pleiotropy
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term for the cytokine action in which many different cytokines may act on a single cell
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redundancy
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term for the cytokine action in which come cytokines work best in assoc. w/ other cytokines
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synergy
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term for the cytokine action in which some cytokines may antagonize the effects of others
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antagonism
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T/F: cytokine receptors are membrane glycoproteins
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T
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name the 2 functional units of cytokine receptors
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ligand binding unit
signal transduction unit |
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name the 2 examples of cytokine control via macrophages
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IL-IRA(receptor agonist)
soluble TNF-R |
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term for the proteins produced by viruses that are closely related to or may affect mammalian cytokines
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virokines
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T/F: virokines inhibit antiviral immune responses
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T
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do TH1 or TH2 cells help B cells?
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TH2
(TH 1 cells help cytotoxic T cells) |
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T/F: the 3 fundamental activities of TGF are: 1) regulte growth, diffentiation, and function of all lymphocytes 2) immunosuppressive 3) enhance the deposition of extracellular matrix proteins
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T
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