Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
40 Cards in this Set
- Front
- Back
|
name of the system that consists of a set of enzymes that destroy microbes (can be activated by both innate and acquired immunity)
|
complement system
|
|
|
name 6 host benefits of the complement system
|
-opsonization to enhance phagocytosis
-phagocyte attraction and activation -lysis of bacteria and infected cells -regulation of antibody responses -clearance of immune complexes -clearance of apoptotic cells |
|
|
name a host detriment of the compliment system
|
inflammation, anaphylaxis
|
|
|
T/F: complement components account for 50% of the globulin fraction of serum
|
F! 15%!
|
|
|
most of C3, C6, C8, and B are made where?
|
liver!
|
|
|
C2, C3, C4, C5, B, D, P and I are made by what cells?
|
macrophages
|
|
|
which cells store large quantities of C6 and C7?
|
neutrophils
|
|
|
name the 5 protein factors assoc. w/ the complement system
|
B, D, H, I, properdin (P)
|
|
|
name 3 inhibitors assoc. w/ the complement system
|
C1 inhibitor (C1-INH, serpin)
C4-binding protein (C4-BP) decay accelerating factor (DAF) |
|
|
when enzymatically cleaved, does the smaller or larger moiety bind to the activation complex?
|
larger!
the smaller is released into the microenvironment (chemotactic factor) |
|
|
T/F: the letter "b" is usually added to the smaller moiety
|
F! added to the larger membrane-binding protein ( remember, b is BIG)
|
|
|
T/F: C2 is the exception to the letter"a/b" naming system
|
T! the larger moiety is C2a
|
|
|
term for alteration of C proteins such that they interact w/ the next component
|
C-activation
|
|
|
term for the utilization of C by Ag-Ab complexes
|
C-fixation
|
|
|
term for dilution of serum which lyses 50% of Ab-coated RBCs in a suspension (CH50)
|
hemolytic units
|
|
|
term for the denaturation of an early C-component resulting in loss of hemolytic activity
|
C-inactivation
|
|
|
term for altered C-protein which acts as a proteolytic enzyme for another C-component
|
convertase/esterase
|
|
|
name the 3 pathways of complement activation (which is antibody dependent?)
|
classical pathway-antibody dependent
lectin pathway alternative pathway |
|
|
which of the 3 pathways of complement activation are antibody independent? (activated by bacteria)
|
lectin pathway
alternative pathway |
|
|
after the initial activation of all 3 complement activation pathways, what do all 3 activate?
|
C3 ( and generation of C3 convertase)
|
|
|
in the common pathway of complment activation, what does the activation of C3 and generation of C3 convertase lead to?
|
activation of C5
|
|
|
name the 2 C3 convertases
|
C3b-Bb-P
C4b2b |
|
|
which 2 of the 3 complement activation pathways use C4b2b?
|
lectin pathway
classical pathway |
|
|
T/F: activation of C3 and C4 not only involves the cleavage of a peptide off of these proteins, but also the cleavage of a thioester bond (enables the molecule to bind irreversibly)
|
T
|
|
|
T/F: C3b is usually inactivated by factors H and I ( but factor H must first be activated by binding to the surface)
|
T
|
|
|
T/F: factor I will not work in the absence of factor H
|
T
|
|
|
T/F: sialic acid inhibits factor H binding to the cell
|
F! it facilitates H binding to cell and helps binding to C3b
|
|
|
with a factor H deficiency, where does C3b build-up (which organ is damaged?)
|
kidneys
|
|
|
complement activation by the lectin pathway is dependent on which enzyme? (C1, MASP-2, or C3b)
|
MASP-2
|
|
|
complement activation by the alternative complement pathway is dependent on which enzyme?(C1, MASP-2, or C3b)
|
C3b
|
|
|
the classic complement activation pathway is dependent on which enzyme? (C1, Masp-2, or C3b)
|
C1
|
|
|
T/F: C5a must be cleaved off of C5 in order for C6 and C7 to be activated
|
T
|
|
|
the termination complement pathway leads to the formation of a....
|
membrane attack complex (poly C9)
|
|
|
what factor finds to convertases and accelerates their decay?
|
decay accelerating factor
|
|
|
T/F: CD59 inhibits C9 polymerization
|
T
|
|
|
T/F: C1 binding to one molecule of Pentamer IgM is sufficient to initiate the classical pathway
|
T
|
|
|
which complement receptor is found on primate RBCs, neutrophils, eosinophils, macrophages, B and some T cells
|
CR1
|
|
|
which complement receptor is found on B cells and acts as a B-cell costimulator?
|
CR2 (CD21)
|
|
|
which complement receptor is an integrin that binds iC3b? (found on macrophages, neutrophils, and NK cells)
|
CR3
|
|
|
which factor deficiency is assoc. w/ the inability to destroy C3b and stimulates the proliferation of mesangial cells
|
Factor H
|
